Gallium lactate

Following subcutaneous injection of gallium lactate (90-100 mg Ga kg ) in rabbits, 96% of the excreted gallium dose was found in the urine (Dudley etal. 1949). Approximately 40% of a gallium dose appeared in the urine of dogs 24 h after intravenous injection of gallium citrate (5 mg Ga kg ) (Dudley and Marrer 1952). 

Gallium is not readily absorbed from the gastrointestinal tract. Chemical examination of the tissues of animals fed 1000 ppm gallium lactate exhibited only trace amounts in the liver, spleen, and kidney, and 1-3 ppm in bone [39]. This suggests that the alkalinity of the intestinal tract is sufficient to convert gallium chloride to the hydroxide or other insoluble complexes. By subcutaneous or intravenous injection, gallium is rapidly deposited in the tissues, particularly in the bone once deposited there it is relatively immobile [40]. Gallium is excreted rapidly in animals, with about 50% excreted by the kidneys within 24 hr [42]. 

In 2001, Chisholm s group reported a (3-diiminate (BDI) gallium-OSiMe3 complex which was unreactive for LA ROP the authors cited substrate binding as the limiting step [76]. Recently, a gallium alkoxide initiator (11) has been reported as an efficient polymerization initiator [72]. The dimeric complex was formed by reaction of GaMe3 with (A)-methyl lactate (Fig. 15). 

Gallium(III) complexes, 129 amines, 129 amino acids, 141 arsenates, 135 borates, 134 borohydrides, 141 bromates, 135 carbonates, 134 caiboxylates, 135 chlorates, 135 citrates, 136 cyanides, 129 dithiocarbamates, 138 ethers, 136 fluorides, 138 germanates, 134 hydrides, 140 iodates, 135 p-ketoenolates, 134 lactates, 136 mixed halides, 139 molybdates, 135 nitrates, 135 peptides, 141 perchlorates, 135... 

Dapsens PY, Kusema BT, Mondelli C, Perez-Ramirez J (2013) Gallium-modified zeolites for the selective conversion of bio-based dihydroxyacetone into C1-C4 alkyl lactates. J Mol Catal A Chem. http //dx.doi.Org/10.1016/j.molcata.2013.09.032... 

The tissue distribution of gallium radionuclides is affected by many factors, such as the extent of neoplasm [62], the presence of inflammatory processes [63], sex hormone status [64], age [65], lactation [66], radiotherapy and chemotherapy treatment [67,68], amount of carrier gallium administered [69,70], and administration of compounds which block plasma protein binding of gallium [62,71]. The mechanism of uptake of Ga in tumors and abscesses has not been definitely established. One proposed mechanism suggests that Ga-transferrin interacts with specific transferrin receptors on the tumor cell, where upon binding to the cell the Ga-transferrin complex... 

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