Galactitol, 2-acetamido-2-deoxy

Borohydride reduction of 2-acetamido-2-deoxy-D-galactose affords 2-acetamido-2-deoxy-D-galactitol,219 whereas oxidation of the benzyl 2-(N-benzyloxycarbonyl)amino or-D-glycoside with oxygen in the presence of platinum oxide, followed by hydrogenolysis of the blocking groups, yields... 

Acetamido-1,2- 0 -cyclohexylidene-5-deoxy-a-D-xylofnranose, A-358 5-Acetamido-5-deoxy-L-arabinopyranose, A-180 2-Acetamido-2-deoxy-D-galactitol, A-188... 

Acetamido-3-6 -benzyl-2-deoxy-D-xylitol, A-355 2-Acetamido-2-deoxy-3,4 5,6-di-0-isopropylidene-D-glucitol, A-215 2-Acetamido-2-deoxy-D-galactitol, A-188 2-Acetamido-2-deoxy-D-glucitol, A-215 2-Acetamido-2-deoxy-D-mannitol, A-301... 

Acetamido-1,3,4,5-tetra-O -acetyl-2,6-dideoxy-D-altritol, A-367 6-O -Acetyl-1 -deoxy-D-galactitol, D-123... 

A micro method for determining the structures of substituted 2-acetamido-2-deoxy-D-galactitol and -glucitol in glycoproteins, etc., has been reported. Aminodeoxy[ H]alditols resulting from periodate oxidation, reduction with sodium borotritide, and hydrolysis of nmole amounts of substituted 2-acetamido-2-deoxyalditols were separated by t.l.c. and detected by autoradiography. 

The mild periodate oxidation of 3- and 6-O-substituted 2-acetamido-2-deoxy-D-galactitols and 4- and 6-O-substituted D-glucitols have been studied, and the major sites of oxidation shown as expected to be threo-diol moieties. The products were characterized by ms of thin layer chromatography samples of the corresponding 1,2-di-0-palmitoyl-sn-g/ycerD-3-phosphoethanolamine derivatives. 

BenzyI-2-acetamido-2-deoxy-a-D-glucopyranoside has been used as starting material for the preparation of 2-acetamido-l,4-imino-l,2.4-trideoxy-D-galactitol 40. ... 

Efficient separations of 2-acetamido-2-deoxy-galactitol, -glucitol and -maiuiitol, and of oUgosaccharide-hexosaminitols released by reductive -elimination from glycopeptides, from other mataials, were achieved by h.p.l.c. with pulsed amperometric detection on a surprising combination a cation-exchange column with dilute NaOH as eluant. Neutral and amino-sugars eluted near the void volume. The cationic polyol surfactants 1 and their synthetic precursors were separated by ion-pair reversed-phase h.p.l.c., and the related non-ionic diamide polyol surfactants 2 were determined by reversed-phase h.p.l.c. ... 

---