GABA receptors and

Pharmacological modulation of GABA -receptor and glycine-receptor channels... 

Egebjerg, Schousboe, and Krogsgaard-Larsen, Eds., Glutamate and GABA Receptors and Transporters Structure, Function and Pharmacology, Taylor Francis, London, 2001. 

Thomsen, C. and Ebert, B. (2002) Modulators of the GABAA receptor complex novel therapeutic aspects, in Glutamate and GABA Receptors and Transporters (Egebjerg, J., Schous-boe, A., and Krogsgaard-Larsen, P., eds.), Taylor Francis, London, pp. 407 127. 

Molecular Neuropharmacology Strategies and Methods is intended to bridge the gap between molecular biology and advanced chemistry. In addition, it attempts to include information about x-ray crystallographic analyses whenever available. This book discusses interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. 

Benzodiazepines. Like the barbiturates, benzodiazepines bind to the GABA receptor and are therefore cross-tolerant with alcohol. As a result, they also make suitable replacement medications for alcohol and are widely used for alcohol detoxification. Theoretically, any benzodiazepine can be used to treat alcohol withdrawal. However, short-acting benzodiazepines such as alprazolam (Xanax) are often avoided because breakthrough withdrawal may occur between doses. Intermediate to long-acting benzodiazepines including chlordiazepoxide (Librium), diazepam (Valium), oxazepam (Serax), lorazepam (Ativan), and clonazepam (Klonopin) are more commonly utilized. 

Baclofen, labeled as a skeletal muscle relaxant binds to GABA receptors and depresses excitation. It is also useful in the treatment of paroxysms of trigeminal neuralgia. Baclofen is effective in patients with carbamazepine-resistant pain and has been used successfully to relieve attacks in patients previously unresponsive to carbamazepine or phenytoin. 

Barnard EA. The molecular biology of GABA receptors and their structural determinants. In Biggio C, Sanna E, and Costa E (eds.). GABAa Receptors and Anxiety From Neurobiology to Treatment. 

The acute effects of ethanol and other sedative-hypnotics are mediated by actions at a number of receptor systems. For example, ethanol inhibits several excitatory receptor systems, including N-methyl-D-aspartate (NMDA) receptors, kainate receptors, and Ca channels. In addition, ethanol enhances the action of GABA at GABA receptors and appears to modulate serotonergic neurotransmission. Although a component of ethanol reinforcement is mediated by the activation of mesocorticolimbic dopamine neurons, activation of these neurons may not be necessary for ethanol reinforcement, as ethanol remains reinforcing in the absence of these neurons (Samson and Harris, 1992 Koob, 2000b). 

Mohler IJ, Evans SJ. g-Aminobutyric acid (GABA), receptors and their association with benzodiazepine recognition sites. In Meltzer HY, ed. Psychopharmacology the third generation of progress. New York Raven Press, 1987 265-272. 

There is little doubt that milbemycins and avermectins act on chloride channels associated with GABA receptors and amplify GABA functions in the mammalian central nervous system. In the free-living nematode, C elegans, however, avermectin was found to interact with glutamate-gated... 

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