Regulators of G-protein Signalling

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PEPCK phosphoenolpyruvate carboxykinase RGS regulators of G protein signaling... 

Calo, L. A., Pagnin, E., Davis, P. A., et al. (2004) Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter s/Gitelman s syndrome. A role in the control of vascular tone and implication for hypertension. J. Clin. Endocrinol. Metab. 89, 4153 157. 

Semplicini, A., Lenzini, L., Sartoii, M., et al. (2006) Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERKl/2 phosphorylation induced by angiotensin 11. J. Hypertens. 24, 1115-1124. 

Fig. 6 Proteins with GPR motifs. (RBD Ras binding domain, PTB phosphotyrosine binding domain, RGS regulator of G-protein signaling domain, PDZ PSD95/DLG/ZO-1 domain, cc coiled-coil domain). This figure is adapted from the thesis of Dr. Yuri Peterson...

Recently, it was discovered that G-protein activity is controlled by another class of proteins. These proteins, termed RGS proteins (for regulators of G-protein signaling), enhance the rate of GTP hydrolysis. This activity reduces the amount of time the G-protein a subunit spends in its active GTP-bound conformation, in effect limiting the response to receptor activation. 

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