G ligands

The chemistry of this interesting series of cyclic selenium imides, e.g., ligand behaviour, has not been investigated. 

Ion channels are often multimeric and are regulated by a wide variety of mechanisms (e.g., ligand binding, voltage changes, phosphorylation). 

G. Ligand Substitution on Octahedral Trivalent Transition Metal Ions... 

Schmid, G. Ligand-stabilized Giant Metal Clusters and Colloids. In Physics and Chemistry of Materials with Low-Dimensional Structures, Kluwer Academics The Netherlands, Longh, J. L. 1994 Vol. 18, pp 107. 

G. Ligand Exchange on Five Coordinated Beryllium Dications 560... 

Prior to the introduction of ion-selective electrode techniques, in situ monitoring of free copper (II) in seawater was not possible due to the practical limitations of existing techniques (e.g., ligand competition and bacterial reactions). Ex situ analysis of free copper (II) is prone to experimental error, as the removal of seawater from the ocean can lead to speciation of copper (II). Potentially, a copper (II) ion electrode is capable of rapid in situ monitoring of environmental free copper (II). Unfortunately, copper (II) has not been used widely for the analysis of seawater due to chloride interference that is alleged to render the copper nonfunctional in this matrix [288]. 

The addition of CaBPs can directly activate the IP3-R in a Ca2+-dependent manner, via interaction with the N-terminus region of the receptor. This raises the possibility that CaBPs can act on IP3-Rs to potentiate the Ca2+ signals that arise from other sources, e.g. ligand-gated ion channels. 

Another special case are bidentate ligands. With an appropriate distance of the two phosphorus atoms, they bind the metal like pincers (chelate structure), shifting the equilibria in Fig. 14 directly to column C. Those ligand systems are known to be appreciably slower than the corresponding bulky monophosphites, but highly regioselective (e.g., ligand 4 in Fig. 9). 

Schldfer, H. L., Gliemann, G. Ligand Field Theory. New York Wiley Interscience 1969... 

The extended X-ray absorption fine structure (EXAFS) portion of the spectrum extends above the edge in energy and arises from interferences between the photoelectron produced at the edge and photoelectrons backscattered by nearby atoms (e.g. ligand donor atoms) (Scott 1985). The frequency of EXAFS oscillations is directly... 

If the polyelectrolyte can coordinate strongly to a metal ion, marked deceleration effects can be noted, as, for example, in the reactions of Ni + and Co + with pad in the presence of polyphosphates. Modifications of equilibria constants in these micelles must also be recognized as contributing to rate change, e. g., ligand pK or keto-enol equilibria may be altered. 

Johnson B.A., Wilson E.M., Li Y, Moller D.E., Smith R.G., Zhou G. Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy implications for nuclear receptor activation. J. Mol. Biol. 2000, 298, 187-194. 

Fig. 8. From left to right Exo-exo, endo-endo and exo-endo conformations of macro-bicyclic ligands of type G, e. g. ligand 30, [2.2.2]...

In early discovery, new chemical entities of interest can be either polar compounds (e.g., peptides, nucleotides, sugars) or non-polar compounds (e.g., ligands or inhibitors maximizing hydrophobic interactions with therapeutic targets). Thus ideal HTS in vitro methods must be able to cover a large range of lipophiiicity values. This goal... 

This reaction can be generalized by replacing the acid by an electron-pair acceptor [Lewis acid (A), e.g., metal ion] and the base by an electron-pair donor [Lewis base (B), e.g., ligand) to give ... 

Horlein, A.J., Naar, A.M., Heinzel, T., Torchia, J., Gloss, B., Kurokawa, R., Ryan, A., Kamei, Y, Soderstrom, M., Glass, C. and Rosenfeld,M.G Ligand independent repression by the thyroid hormone receptor mediated by a nnclear repressor co-repressor (1995) Natnre 777, 397-404... 

Selected values oi / and g Ligand f (actor Metal ion g (actor6... 

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