Urticaria furosemide

Ethacrynic acid Adverse reactions may include anorexia, pain, Gl bleeding, severe neutropenia, agranulocytosis, fever, chills, confusion, fatigue, malaise, sense of fullness in the ears, blurred vision, tinnitus, hearing loss (irreversible), rash. Furosemide Adverse reactions may include anorexia, cramping, constipation, blurred vision, hearing loss, restlessness, fever, anemia, purpura, thrombocytopenia, agranulocytosis, photosensitivity, urticaria, pruritus, thrombophlebitis, muscle spasm, weakness. 

All sulfonamides and their derivatives, including carbonic anhydrase inhibitors, thiazides, furosemide, bumetanide, torsemide, diazoxide, and the sulfonylurea hypoglycemic agents, are cross-allergenic. The most common adverse effects are fever, skin rashes, exfoliative dermatitis, photosensitivity, urticaria, nausea, vomiting, diarrhea, and difficulties referable to the urinary tract (see below). Stevens-Johnson syndrome, although relatively uncommon (ie, less than 1% of treatment courses), is a particularly serious and potentially fatal type of skin and mucous membrane eruption associated with sulfonamide use. Other unwanted effects include stomatitis, conjunctivitis, arthritis, hematopoietic disturbances (see Urinary Tract Disturbances), hepatitis, and, rarely, polyarteritis nodosa and psychosis. 

In many types of drug reactions, bullae and vesicles may be found in addition to other manifestations. Bullae are usually noted in erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, fixed eruptions when very intense, urticaria, vasculitis, porphyria cutanea tarda, and phototoxic reactions (from furosemide and nalidixic acid). Tense, thick-walled bullae can be seen in bromoderma and iododerma as well as in barbiturate overdosage. 

Desensitization to drugs is increasingly being described by the use of initially tiny doses, gradually increasing to therapeutic doses, sometimes over very short periods of time [SEDA-30, 416 SEDA-33, 494]. A rapid oral desensitization protocol for furosemide has been described (Table 1) and used successfully in a 44-year-old woman who developed urticaria while taking furosemide [49 ]. Previous protocols have involved rapid intravenous administration (Table 2) or oral administration over 3 days (Table 3) [51 ]. 

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