Fundic gland polyps

Declich P, Ferrara A, Galati F, Caruso S, Baldacci MP, Ambrosiani L. Do fundic gland polyps develop under long-term omeprazole therapy Am J Gastroenterol 1998 93(8) 1393. 

Naegels S, Urbain D. Omeprazole and fundic gland polyps. Am J Gastroenterol 1998 93(5) 855. 

Burt RW. Gastric fundic gland polyps. Gastroenterology. 2003 125 1462-1469. 

Declich P, Isimbaldi G, Sironi M, et al. Sporadic fundic gland polyps an immunohistochemical study of their antigenic profile. Pathol Res Pract. 1996 192 808-815. 

Sekine S, Shibata T, Yamauchi Y, et al. Beta-catenin mutations in sporadic fundic gland polyps. Virchows Arch. 2002 440 381-386. 

Hassan A, Yerian LM, Kuan SF, et al. Immunohistochemical evaluation of adenomatous polyposis coli, beta-catenin, c-Myc, cyclin Dl, p53, and retinoblastoma protein expression in syndromic and sporadic fundic gland polyps. Hum Pathol. 2004 35 328-334. 

A prospective study of 1780 consecutive upper gastrointestinal endoscopies showed a prevalence of gastric polyps of 7.2% ( = 129) within this subgroup, 77 patients (4.3%) had fundic gland polyps [77. Proton pump inhibitors had been used by 64% of patients with fundic polyps and 16% of those without polyps. Multiple regression analysis showed that three... 

Hongo M, Fujimoto K, Gastric Polyps Study Group. Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy a prospective study in Japan. J Gastroenterol 2010 45 618-24. 

Zelter A, Fernandez JL, Bilder C, Rodriguez P, Wonaga A, Dorado F, Galich M, Viola LA. Fundic gland polyps and association with proton pump inhibitor intake a prospective study in 1,780 endoscopies. Dig Dis Sci 2011 56 1743-8. 

An uncontrolled retrospective study of patients who had taken proton pump inhibitors for an average of 33 months found gastric polyps in 17 of 231 patients who underwent two or more endoscopies for complicated gastro-esophageal reflux disease (33). The polyps were generally small (under 1 cm), sessile, and multiple, and were present in the proximal or mid gastric body. Of the 15 polyps removed endoscopically, nine were fundic gland type, four were hyperplastic, and two were inflammatory. None had any dysplasia or carcinoma. 

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