Functional groups physiochemical properties

CE is an analytical separation technique capable of high-resolution separation of a diverse range of chemical compounds and is therefore well suited for metabolomics.17,64 It is particularly suitable for the separation of polar and charged compounds and compounds with widely different structures, functional groups, physiochemical properties, and concentrations, for example, organic acids, amino acids, nucleic acids, steroids, carbohydrates, and flavonoids in various matrices. CE is complementary to GC and HPLC, and in many cases, samples that cannot be... 

Ephraim J., Alegret S., Mathuthu A., Bicking M., Malcolm R. L., and Marinsky J. A. (1986) A united physiochemical description of the protonation and metal ion complexation equilibria of natural organic acids (humic and fulvic acids) 2. Influence of polyelectrolyte properties and functional group heterogeneity on the protonation equilibria of fulvic acid. Environ. Sci. Technol. 30, 354-366. 

FIGURE 4.3 The variety of ProteinChip arrays available for sample preparation. (A) The upper arrays represent chemically modified chromatographic surfaces, while the bottom arrays are biochemically modified surfaces. Chemically modified surfaces are used to retain a group of proteins, while biochemically modified surfaces are typically used to isolate a specific protein or functional class of proteins. (B) Protein profile of a cell lysate on different ProteinChip surfaces. As shown in the figure for a selection of protein chips, the individual surfaces retain different groups of proteins, depending on their physiochemical properties. The proteins retained are also dependent on the pH of the sample for the cation and anion exchange surfaces. 

Having physiochemical properties that improve probability of success in drug development by addressing issues of absorption and bioavailability including the filtering out of chemically reactive functional groups and peptides, compliance with ROF, etc. ... 

Given the complex biological and chemical interaction between the polymeric implants and the in vivo environment of the host, the physiochemical properties of the polymers must be carefully considered in the selection of polymeric biomaterials that are biochemically appropriate for specific applications in implantable prostheses. Overall, the ideal material should minimize its adverse effects on the host tissues and immune system while resisting hydrolytic and oxidative degradation to achieve successful device integration and the intended long-term functionality. In addition, the choice of materials depends not only on the functions of the prostheses but also on other factors such as the site of implantation, the age group of recipients, and the intended period of use. 

---