Function-oriented synthesis

P. Reiss and U. Koert, Ion-Channels Goals for Function-Oriented Synthesis, Acc. Chem. Res., 2013, 46, 2773. 

The efficiency of total synthesis should then benefit to the growing research efforts in chemical biology and drug discovery in the future, in connection with recently designed strategies like diversity-oriented synthesis (DOS) and function-oriented synthesis (FOS). 

Wender PA, Verma VA, Paxton TJ, Pillow TH, Function-oriented synthesis, step economy, and drug design. Acc. Chem. Res. 2008 41(1) 4[Pg.343]

Structural type. Diversity-oriented synthesis is a new strategy for constructing libraries with both skeletal and functional group diversity. 

Multicomponent reactions (MCRs) are one-pot processes combining three or more substrates simultaneously [1], MCR processes are of great interest, not only because of their atom economy but also for their application in diversity-oriented synthesis and in preparing libraries for the screening of functional molecules. Catalytic asymmetric multicomponent processes are particularly valuable but demanding and only a few examples have been realized so far. Here we provide an overview of this exciting and rapidly growing area. 

The development of synthetic methods is a very important branch of natural product synthesis, and complex target-oriented synthesis. The new chemical methods that are developed by chemists simplify the process of synthesis. This simplification generally leads to a shorter number of steps in the synthesis and therefore a more efficient synthesis. New synthetic methods are usually developed with simple substrates which highlight the main functional group transformation. These methods can be difficult to be transferred to a more complex molecule therefore, it is important that a new synthetic method demonstrates the scope and limitation of the method. 

Scheme 5. Inversion strategy and further functionalizations for the diversity oriented synthesis of carbohydrate derivatives...

Muller TJJ (2007) Diversity-oriented synthesis of chromophores by combinatorial strategies and multi-component reactions. In Muller TJJ, Bunz UHF (eds) Functional organic materials. Syntheses, strategies, and applications. Wiley-VCH GmbH KGaA, Weinheim, pp 179-223... 

Diversity-Oriented Synthesis of Small Molecules Natural Product Inhibitors to Study Biological Function Nucleic Acid Synthesis, Key Reactions of Proteins Stmcture, Function and Stability Solution-Phase Synthesis of Biomolecules... 

FIGURE 10.10 A scanning electron microscopy (SEM) analysis of l>-oriented SIL-1 layers over Si wafers (prepared by secondary growth using dip-coating as seeding technique) as a function of synthesis time. 

In the late 1990s, the group led by Schreiber introduced the concept of diversity-oriented synthesis (DOS) [18-20] into the field of organic chemistry. In combination with the split-pool synthesis [21,22] and tagging strategies [23,24], DOS allowed chemists to prepare large collections of structurally diverse small molecules. The library compounds are usually prepared on polymeric beads, and thus each compound contains a common functional group that mediates covalent attachment to the solid surface. 

The classical function-oriented automation concept forfeits efficiency the instant a diversity of process and products are targeted. On the other hand, by centralizing automation, i.e., by devolving automation tasks away from the periphery to a powerful central robot, highly variable processes can be tackled, e.g., in combinatorial synthesis. One feature of these so-called sample-oriented systems is that the pipetting function is centralized. 

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