Fumonisin binding

Lactobacillus and Propionibacterium strains were evaluated by El-Nezami et al. (2002) regarding their ability to remove seven Fusarium toxins (trichothecenes) from solution. Results showed that L. rhamnosus GG and Propionibacterium freudenrei-chii spp. shermanii JS were able to bind 18-93% of the deoxynivalenol, diacetoxy-scirpenol, and fusarenon in solution, while L. rhamnosus LC-705 removed 10-64% of deoxynivalenol and diacetoxyscirpenol from liquid medium. When comparing the ability of lactic and propionic bacteria to remove toxin from solution, Niderkom, Boudra, and Morgavi (2006) found that deoxynivalenol and fumonisin removal was strain specific, and that in general propionic acid bacteria was less efficient than lactic acid bacteria. The best results were achieved with L. rhamnosus for ranoval of deoxynivalenol (55%), Leuconostoc mesenteroides for fumonisin Bi (about 82%), and L. lactis for fumonisin B2 (100%) (Niderkom et al., 2006). 

Several Fusarium toxins such as DON, fumonisins, fusarenon-x, fusaric acid, nivalenol, T-2, HT-2 and ZEA are prone to masking biofransformations or binding by plants (Berthiller et al., 2013). In addition, other mycotoxins such as OTA and patulin have been found in conjugated forms. The major form of modified DON is deoxynivalenol-3-p-D-glucopyranoside (D3G), which is perhaps the most widely studied cereal-associated modified mycotoxin so far. 

Ramirez CM, Davalos A, Goedeke L, et al. MicroRNA-758 regulates cholesterol efflux through posttranscrip-tional repression of ATP-binding cassette transporter Al. Arterioscler Thromb Vase Biol. 2011 31(11) 2707-2714. Merrill Jr AH, SuUards MC, Wang E, Voss KA, Riley RT. Sphingolipid metabolism roles in signal transduction and disruption by fumonisins. Environ Health Perspect. 2001 109(suppl 2) 283-289. 

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