4.15- Diacetoxy scirpenol

Coppock, R.W., Gelherg, H.B., Hoffrnarm, W.E., Buck, W.B. (1985a). The acute toxicopathy of intravenous diacetoxy-scirpenol (anguidine) administration in swine. Fundam. Appl. Toxicol. 5 1034-A9. 

Type A consists of T-2, HT-2 toxin, diacetoxy-scirpenol (DSA) which are produced by Fusarium sporitrichioides, Fusarium tricimctum, Fusarium Poae. 

Ripperger H, Seifert K, Romer A, RuUkotter J (1975) Isolierung von Diacetoxy-scirpenol aus Fusarium solani var. coeruleum. Phytochemistry 14 2298... 

Ghosal S, Biswas K, Srivastava RS, Chakrabaiti DK, Chaudhaiy KCB (1978) Toxic Substances Produced by Fusarium, V Occurrence of Zearalenone, Diacetoxy-scirpenol, and T-2 Toxin in Moldy Com Infected with Fusarium moniliforme Sheld. J Pharm Sci 67 1768... 

Lactobacillus and Propionibacterium strains were evaluated by El-Nezami et al. (2002) regarding their ability to remove seven Fusarium toxins (trichothecenes) from solution. Results showed that L. rhamnosus GG and Propionibacterium freudenrei-chii spp. shermanii JS were able to bind 18-93% of the deoxynivalenol, diacetoxy-scirpenol, and fusarenon in solution, while L. rhamnosus LC-705 removed 10-64% of deoxynivalenol and diacetoxyscirpenol from liquid medium. When comparing the ability of lactic and propionic bacteria to remove toxin from solution, Niderkom, Boudra, and Morgavi (2006) found that deoxynivalenol and fumonisin removal was strain specific, and that in general propionic acid bacteria was less efficient than lactic acid bacteria. The best results were achieved with L. rhamnosus for ranoval of deoxynivalenol (55%), Leuconostoc mesenteroides for fumonisin Bi (about 82%), and L. lactis for fumonisin B2 (100%) (Niderkom et al., 2006). 

Rosenstein, Y., LaFarge-Frayssinet, C., Lespinats, G., Loisillier, LaFont, P., and Frayssinet, C. (1979). Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts ofcrude extracts. T2-toxin and diacetoxy-scirpenol. Immunol. 36 111-118. 

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