Fuels and generation of ATP in immune cells consequences for a patient

Fuels and generation of ATP in immune cells consequences for a patient 

The response of the body to an invasion by a pathogen involves not only the immnne system bnt other tissnes in which changes in metabolism are essential for a satisfactory response. These inclnde adipose tissne, mnscle and liver, all of which provide precnrsor molecnles (i.e. bnilding materials) for the synthesis of the macromolecnles required for proliferation (Table 17.5). In addition, they provide fuels, the oxidation of which generates ATP for the immune cells, particnlarly to snpport proliferation of the cells in the lymph nodes bnt also for the precnrsor cells in the bone marrow where proliferation increases to prodnce new immune and other cells (Table 17.6). 

The total nnmber of lymphocytes in the body is about 10 but when all immune cells are included the total number is probably greater than in many organs (e.g. liver. 

DNA and RNA synthesis De novo formation of purine and pyrimidine nucleotide Nucleoside diphosphate reductase Thymidylate synthase Polymerase reactions Chapter 20 

Synthesis and degradation of cychns Peptide and protein synthesis Protein kinase reactions Mitosis 

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FUELS AND GENERATION OF ATP IN IMMUNE CELLS CONSEQUENCES FOR A PATIENT... 

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