Fruton, Joseph

Fruton, Joseph S. "Contrasts in Scientific Style Emil Fischer and Franz Hofmeister Their Research Schools and Their Theories of Protein Structure." Proceedings of the American Philosophical Society 129 (1985) 313370. 

Fruton, Joseph S. and Simmonds, Sofia. General Biochemistry. Second Edition. John Wiley Sons, Inc., New York. 1958. 

Fruton, Joseph. Molecules and Life. New York Wiley, 1972. 

Fruton, Joseph S. Molecules and Life (Wiley-Interscience, New York, 1972). 

Fruton, Joseph S. (pp. 56,246, Plate 18), born in 1911 in Czestochowa, Poland Ph.D. at Columbia University, New York, in 1934, at the Rockefeller Institute with Max Bergmann 1934-1935 (p. 47). In 1945 he became Associate Professor of Physiological Chemistry at Yale University, New Haven, Conn., Chair of the Department of Biochemistry 1951-1967, Eugene Higgins Professor of Biochemistry 1957-1982, Professor of the History of Medicine 1980-1982. Published, among others. General Biochemistry (with S. Simmons, 1953), Molecules and Life (1972), and selected articles on the History of Biochemistry and Chemistry since 1800. 

James D. Watson, TheDoubleHelix—A Personal Acount of the Discovery of the Structure ofDNA (Atheneum, New York, 1968), p. 20. Copyright 1968, James D. Watson. Joseph S. Fruton, A Skeptical Biochemist (Harvard University Press, Cambridge, MA, 1992), p. 224. 

Joseph F. Fruton, Contrasts in scientific style (Philadelphia, 1990). 

In the 1930s, Max Bergmann and his student Joseph Fruton synthesized short peptides of known composition and sequence so that they could determine what bonds pepsin splits. Pepsin, they found, accelerates the hydrolysis of a bond containing the amino group of tyrosine or phenylalanine. Thus, pepsin liberates tyrosine or phenylalanine from... 

My approach in studying tryptophan synthetase was greatly influenced by the rigorous training in enzymology I had at Yale in tutorial and laboratory courses with the biochemist Joseph Fruton. Because of this experience, I was determined to purify the protein and characterize it further before I attempted an analysis of the available mutant strains. This was a wise decision, I feel, because there was much to learn about the enzyme. From my studies I concluded that the previously reported activation of a possible tryptophan synthetase precursor was in error. The initial investigators also failed to repeat the activation. ... 

---