Frontoparietal cortex

Ruggeri M, Merlo Rich E, Zini I, Fuxe K, Ungerstedt U, et al. 1990. Indole-pyruvic acid increases 5-hydroxyindoleacetic acid levels in the cerebrospinal fluid and frontoparietal cortex of the rat a microdialysis study. Acta Physiol Scand 138(1) 97-98. 

Microdialysis experiments show that BEO (0.5 ml/kg) did not affect basal amino acid levels, whereas it significandy reduced the efflux of excitatory amino acid, namely aspartate and glutamate, in the frontoparietal cortex typically observed following MCAo (Fig. 2). Extracellular levels of glycine, GABA,... 

Fig. 2. BEO significantly reduces excitatory amino add (Asp and Glu) efflux in the frontoparietal cortex typically observed following MCAo. Effect of BEO (B solid line) or vehicle (V dotted line) administration (B/V, 0.5 ml/kg, i.p., 1 h before MCAo) on dialysate levels of glutamate, aspartate, glutamine, glycine, citrulline, taurine, and GABA detected in the upper frontoparietal cortex following pMCAo. Data are mean S.E.M. (n = 3 per group) P < 0.05, P < 0.01, P < 0.001 versus vehide, Student s Mest.

Kami-untan-to (KUT) > Kampo traditional preparation for treating age-related memory loss and dementia. oral administration increased choline acetyltransferase activity in frontoparietal cortex and reduced cognitive impairment in forebrain-lesioned rats. KUT indirectly increases available achetylcholine by inducing increased transcription of choline acetyltransferase (ChAT) and Nerve Growth Factor (NGF) mRNA. putative mechanism is stimulated NGF production resulting in increased ChAT production, and indirectly, increased Acetylcholine production (ACh). 

EGb-761 Rats 50 mg/kg/day decreases in glucose utilization in the frontoparietal somatosensory cortex, nucleus accumbens, cerebellar cortex, and pons [50]... 

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