From Lonchocarpus sericeus

Lonchocarpin, which is apyranochalcone, isolated from Lonchocarpus sericeus showed significant antiplatelet effect. The effect was suggested to be mediated by phosphodiesterase activity by inhibition or elevation of intracellular levels of adenosine 3 5 -cyclic monophosphate and guanosine 3 5 -cyclic monophosphate [81]. Crotaramosmin isolated from Crotalaria ramosissima showed weak antima-larial activity and strong antileishmanial effect [64]. 

Eontenele JB, Leal LKAM, Ferreira MAD, Silveira ER, Viana GSB (2005) Antiplatelet Effect of Lonchocarpin and Derricin Isolated from Lonchocarpus sericeus. Pharm Biol 43 726... 

Aminoimidazole has been isolated from the seeds of Mundulea sericea (Willd.) A. Chev., a leguminous shrub from tropical Africa and Asia (233). The alanyl derivative of 2-aminoimidazole, enduracididine (165), and 2-[2-amino-2-imidazolin-4-yl]acetic acid have been obtained from the seeds of the legume Lonchocarpus sericeus (Poir) H.B. and K., native to the West Indies, tropical America, and West Africa (234). 

The spiro piperidine (77) is a constituent of the seeds of the leguminous plants Lonchocarpus sericeus and L. costaricensis (L.E. Fellows et al., Chem.Comm., 1979, 977), and the simple phenacylpiperidine (78) is an antifungal agent from the plant Boehermia cyclindrica (W. Dopke et al., Z.Chem., 1981, 21, 358). Other piperidines include dumetorine (79), which is obtained from the yam Pioscorea dumetorum (D.G. Corley, M.S. Tempesta and M.M. Iwu, Tetrahedron Letters, 1985, 26, 1615), and the simple glucoside (80) an extractive of Xanthocercis zambesiaea (S.V. Evans et al., ibid., p 1465). 

C H,3N04, Mr 163.17, mp. 188°C, [a]g -26.7° (CH3OH). A piperidine alkaloid, mannosidase inhibitor from the seeds of Lonchocarpus sericeus and L. co-staricensis (Fabaceae) as well as from cultures of Streptomyces lavendulae. 

A series of piperidine alkaloids with hydroxyl substitutions have been isolated from a number of higher plants (54-56) (Fig. 29.19) (Herbert, 1986, 1988). Among these plant species are Lonchocarpus sericeus, L. costaricensis and Derris elliptica (Fabaceae), Moms species (Moraceae), Fagopyrum esculentum (Polygonaceae), and a fern of the... 

Dideoxy-2,5-imino-D-mannito I Alkaloid from the leaves of Derris elliptica and the seeds of Lonchocarpus sericeus (Leguminosae). Glycosidase inhibitor. Cryst. (EtOH/MezCO/EtOAc). 

Alkaloid from the seeds of Lonchocarpus sericeus, Lonchocarpus costaricensis (Leguminosae), Commelina communis and Streptomyces lavendulae. Mannosidase inhibitor. a-Glucosidase inhibitor. 

DNJ - deoxynojirimycin, first shown as microbial metabolite, was found in roots of Moms spp (Moraceae) (77). It is clear that this compoimd can be seen as an azapyranose analog of glucose. The respective mannose analog DMJ -deoxymannojirimycin, has been isolated from seeds of the tropical legume Lonchocarpus sericeus 12). DNJ and DMJ are inhibitors of a-glucosidase and mannosidase respectively. 

---