From Laboratory to Clinic

Sneader, W. (1986). Drug Development From Laboratory to Clinic. Wiley, New York. Spector, R., Park, G.D., Johnson, G.F., and Vessell, E.S. (1988). Therapeutic drug monitoring, Clin. Pharmacol. Therapeu. 43 345-353. 

K. Bush, /3-Lactamase Inhibitors from Laboratory to Clinic , Clin. Microbiol. Rev. 1988, 1, 1-119. 

Seymour, L. W, K. Kataoka, andA. V. Kabanov. 1998. Cationic block copolymers as self-assembling vectors for gene delivery. IrSelf-Assembling Complexes for Gene Delivery from Laboratory to Clinical,Trial edited by A. V. Kabanov, L. W. Seymour, and R Feigner, John Wiley, Chichester. 

Kabanov, A.V., Feigner, P.L. and Seymour, L.W. (eds.) (1998a) Self-Assembling Complexes for Gene Delivery. From Laboratory to Clinical Trial. Chichester, New York, Weinheim, Brisbane, Singapore, Toronto John Wiley. 

The transition of gene transfer experiments from laboratory to clinic requires the incorporation of control systems for manufacturing, quality, and the clinic. Clinical-grade rAAV vectors are... 

Geschwind DH. DNA microarrays translation of the genome from laboratory to clinic. Lancet Neurol 2003 2 275-282. 

Vucenik, I., and Shamsuddin, A.M., 2003, Cancer inhibition by inositol hexaphosphate (IP6) and inositol From laboratory to clinic. J. Nutr. 133 3778S-3784S. 

Successful translation of results from laboratory to clinic depends on ... 

Dean, E. J., Ranson, M., Blackball, R, Holt, S. V, Dive, C. Novel therapeutic targets in lung cancer inhibitor of apoptosis proteins from laboratory to clinic. Cancer Treat. Rev. 2007, 33, 203-212. 

Sneader W. Drug Development From Laboratory to Clinic. Chichester Wiley, 1986. 

Boyd J E (1999). Facilities for large-scale production of vectors under GMP conditions. In A Meager (ed.). Gene Therapy Technologies, Applications and Regulations—from Laboratory to Clinic John Wiley Sons LTD, Chichester, UK, pp. 383-400. 

Rihova B, Jelinkova M, Plundrova D, Kovar M, Novak M, Strohalm J, Pechar M, Ulbrich K. Mechanisms of action of polymeric drugs. Proceedings of the Third International S3un-posium on Polymer Therapeutics From Laboratory to Clinical Practice. January 1998, London, UK, p. 9. 

Musila R, Duncan R. Synthesis and evaluation of N-(2-hydro-xypropyl)methacrylamide (HPMA) copolymer-melittin a potential novel anticancer approach. Proceedings of the Fourth International Symposium on Polymer Therapeutics From Laboratory to Clinical Practice, London, UK, January 2000, p. 78. 

Rice JR, Stewart DR, Safaei R, Howell SB, Nowotnik D. Preclinical development of water-soluble polymer-platinum chemotherapeutics AP5280 and AP5286. Proceedings of the Fifth International Symposium on Polymer Therapeutics From Laboratory to Clinical Practice, Cardiff, UK, 2002, p. 54. 

Cerundolo V, Hermans IF, Salio M. Dendritic cells a journey from laboratory to clinic. Nat Immunol 2004 5 7-10. 

Bessa PC, Casal M, Reis RL. Bone morphogenetic proteins in tissue engineering the road from laboratory to clinic, part II (BMP delivery). J Tissue Eng Regen M 2008 2 81-96. 

For nanoceramics like calcium phosphates, the transfer of research outcomes from laboratory to clinical beds is relatively faster compared to other nanomaterials. To date, plenty of conventional ceramics have been successfully used in orthopedics for a long period of time with excellent or satisfactory safety and efficacy records. Therefore, it is expected that the nanostructured version of such ceramics may first become available for clinical use in the near future. Indeed, there are already some commercialized orthopedic nanoceramics that have reached or are close to product launch, which is summarized below. 

Linte CA, Davenport KP, Cleary K, Peters C, Vosburgh KG, Navab N, et al. On mixed reality environments for minimally invasive therapy guidance systems architecture, successes and challenges in their implementation from laboratory to clinic. Comput Imaging Graph 2013b 37 83—97. 

Kabanov AV, Feigner PL, Seymour LW (1998) Self-assembling complexes for gene delivery from laboratory to clinical trial. Wiley, Chichester... 

Russell-Jones GJ (1998) Grit Rev Ther Drug Carrier Syst 15 557 Kabanov AV, Feigner PL, Seymoiu- LW (1998) Self-assembling complexes for gene delivery From laboratory to clinical trial. Wiley, Chichester, p 442 Kabanov AV, Batrakova EV, Sriadibhatla S, Yang Z, Kelly DL, Alakov VY (2005) J Control Release 101 259... 

TorchUin, V. P., 1998, In vitro and in vivo availability of liposomes. In Self-assembling complexes for gene delivery From laboratory to clinical trial (A. V. Kabanov, P. L. Feigner and L. W. Seymour eds), John WUey, Chichester, New York, Weinheim,... 

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