Friability changes

Administration of penicillamine has been associated with many adverse reactions, some of which are potentially serious and even fatal. The nurse carefully evaluates any complaint or comment made by the patient and reports it to the primary health care provider. Increased skin friability may occur, which may result in easy breakdown of the skin at pressure sites, such as the hips, elbows, and shoulders. If the patient is unable to ambulate the nurse changes the patient s position and inspects pressure sites for skin breakdown every 2 hours. 

Purulent drainage from the ulcer is indicative of infection. When pus and inflammatory symptoms are not present, the clinician must be astute to more subtle findings. These include delayed healing, increase in lesion size, prolonged exudate production, malodor, and tissue friability. Abnormal granulation tissue also may be present, as evidenced by color change (from... 

Binder Different binders have different binding properties and the concentration of an individual binder may have to be changed to obtain similar binding of primary particles. Thus, the type of binder, and binder content in the formulation and concentration of the binder have major influence on granule properties. These properties include friability, flow, bulk density, porosity, and size distribution. 

Evaluation of the hardness or friability of a tablet after certain changes. 

Friability is of interest primarily because friable coals yield smaller proportions of the coarse sizes that may (depending on use) be more desirable, and there may also be an increased amount of surface in the friable coals. This surface allows more rapid oxidation hence, conditions are more favorable for spontaneous ignition, loss in coking quality in coking coals, and other changes that accompany oxidation. These economic aspects of the friability of coal have provided the incentive toward development of laboratory friability tests. 

Uanagement of Test-Retest VariabiBty. One way to manage test-retest friability is to increase the size or intensity of the stimulus presented. However, this modification would be at the expense of sensitivity to change. That is, it would take a significantly greater degree of retinal... 

For additional comments and conclusions see Section 4.2.2.3.5 Segregation during feeding and filling also leads to density variations due to local changes in size distribution and, in the case of mixtures, to differences in the plasticity and/or friability of the component materials. Since there is evidence that macroscopic flow of powder during compaction is negligible. 

The pharmacokinetios of interferon is not well understood. Maximum levels in blood after intramuscular injection was obtained in 5 to 8 hours. Interferon does not penetrate well into cerebrospinal fluid (CSF). Oral administration of interferon does not indicate a detectable serum level, and as such, oral administration is olinioally ineffective. After intramuscular or suboutaneous injection, drug concentration in plasma is dose related. Clinioal use of interferon is limited to topioal administration (nasal sprays) for prophylaxis and treatment of rhinovirus infections. Adverse reaotions and toxioity include influenza-like syndrome of fever, ohills, headaohe, myalgias, nausea, vomiting, diarrhea, bone marrow suppression, mental confusion, and behavioral changes. Intranasal administration produoes mucosal friability, ulceration, and dryness. 

Oxidation or ageing of the bitumen affects the mechanical behaviour of the bitumen and usually reduces the pavement s service life. The changes that occur are as follows reduction of penetration, increase of softening point, reduction of elasticity and adhesion ability and increase of friability. Oxidation and ageing can be decelerated with the use of chemical additives. 

Millili and Schwartz demonstrated the effect of granulating with water and ethanol at various ratios. The physical properties of the spheres changed significantly as the ratio of the two fluids was varied. Spheres could not be formed with absolute ethanol but were possible with 5 95 waterlethanol. An increase in the water fraction resulted in a decrease in porosity, friability, dissolution, and compressibility and an increase in density. The porosity of spheres granulated with 95% ethanol was 54%... 

All starch-based foams have significantly higher foam and bulk densities and open-cell and moisture contents than EPS-based foams. Both product types have similar compressive stresses, resiliencies, and friabilities. Starch-based foams are more sensitive to changes in relative humidity and temperature than EPS-based foams, but the larger amounts of absorbed moisture do not compromise mechanical integrity. 

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