Fourier transform MS

Li, Y. Mclver, R.T., Jr. Hunter, R.L. High-Accuracy Molecular Mass Determination for Peptides and Proteins by Fourier Transform-MS. Anal Chem. 1994, 66, 2077-2083. 

Li, Y. Tang, K. Little, D.P. Koester, H. Mclver, R.T., Jr. High-Resolution MALDl Fourier Transform-MS of Oligonucleotides. Anal. Chem. 1996, 68,2090-2096. 

O Connor, P.B. Costello, C.E. A High Pressure MALDl Fourier Transform-MS Ion Source for Thermal Stabilization of Labile Biomolecules. Rapid Commun. Mass Spectrom. 2001, 75, 1862-1868. 

Fourier Transform MS Fourier transform mass spectrometry (FTMS), which is a modem manifestation of ion cyclotron resonance, relies on the collection of ions in a high-vacuum cell and containment with a magnetic field. The ions orbit about the magnetic field axis. The ion masses and... 

Fourier transform MS is an indispensable analyzer for large molecules such as proteins but is not well suited for fast and sensitive screening of target compounds for the purposes of threat analysis. 

Relative to GC-MS, the application of LC-MS within the metabolomics held is still at a preliminary stage. Reproducibility is a major concern, and true quantification can be hindered by ion suppression effects whereby one co-eluting metabolite affects the ionization of another (26). The lack of electrospray ionization mass spectral libraries also makes identification by LC-MS a particularly challenging problem. Nevertheless, the technique is developing fast and has benefited from several technological advancements such as the acquisition of accurate mass data by the use of ion cyclotron resonance Fourier transform MS (26). 

There are several other types of MS instruments like the Fourier transform MS (FT-MS, which was originally called an ion cyclotron resonance or ICR-MS) or the accelerator mass spectrometer (AMS) in which the ion beam is accelerated by an extremely high electric field and then separated by a strong magnetic field (see next section). 

Mass analysers A mass analyser is used to separate ions in a mass spectrometer. The most popular ones used today are quadrupoles, ion traps, time-of-flight (TOF), Fourier transform MS (FTMS) and hybrids based on the combination of these. 

Gas chromatography, using bonded-phase, fused-silica capillary columns, is the most commonly employed procedure for the separation of minor and trace hydrocarbon components. A variety of detectors are used the most common is flame ionization for generic quantitation, magnetic sector, and quadrupole MS and MS/MS for biomarker compounds (43), element-specific detectors for het-eroatomic and metallocompounds (44), and high-resolution MS for measurement of carbon (45) and hydrogen (46) isotopic ratios. Ultra-high-resolution Fourier transform MS (FTMS) coupled with soft-ionization techniques offers the opportunity to detect trace petroleum components without prior enrichment (47). 

Photoionizalion Muss analyzer Magnetic sector Quadrupolc analyzer Quadrupole ion trap analyzer Timc-of-flighl MS Fourier transform MS Electrical detection Data statitms... 

Chiarelli, M. R, M. L. Gross, D. A. Peake, Surfactants on textiles by laser desorption-Fourier transform MS, Anal. Chim. Acta, 1990,228, 169-176. 

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