Foundations of modern biochemistry

FOUNDATIONS OF MODERN BIOCHEMISTRY A Multi-Volume Treatise, Volume 1... 

Foundations of modern biochemistry / editors, Margery C. Ord and Lloyd A. Stocken. p. cm. 

Teich, M. (1965). On the historical foundations of modern biochemistry. Clio Medica 1 414-457. 

Nowit s the turn of the fundamental science oflife, modern biochemistry, to disturb. The simplicity that was once expected to be the foundation of life has proven to be aphantom instead, systems of horrendous, irreducible complexity inhabit the cell. The resulting realization that life was designed by an intelligence is a shock to us in the twentieth century who have gotten used to thinking of life as the result of simple natural laws. But other centuries have had their shocks, and there is no reason... 

Thiamin was the first of the vitamins to be demonstrated to have a clearly defined metabolic function as a coenzyme indeed, the studies of Peters group in the 1920s and 1930s laid the foundations not only of nutritional biochemistry but also of modern metabolic biochemistry and neurochemistry. Despite this, the mechanism by which thiamin deficiency results in central and peripheral nervous system lesions remains unclear in addition to its established coenzyme role, thiamin regulates the activity of a chloride transporter in nerve cells. 

The introduction of ion-exchange chromatography to the determination of amino acid compositions ranks as one of the most significant landmarks in modern biochemistry. The foundation of our knowledge of protein structure and function rests on this technology, which in turn has fundamentally influenced all phases of biological research. The complete resolution... 

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