Foscarnet

Antiviral Efficacy and Clinical Use. Foscarnet (Fos-cavir) is primarily given to treat CMV retinitis in patients with AIDS.6,24 This agent may also help control other infections in patients with a compromised immune system, including serious cytomegaloviral infections (pneumonia, gastrointestinal infections) and some herpesvirus infections (herpes simplex, varicella-zoster). [Pg.529]

Mechanism of Action. Foscarnet works somewhat like acyclovir and ganciclovir that is, foscarnet inhibits the DNA polymerase enzyme necessary for viral DNA replication. Foscarnet differs from these other antiviral drugs, however, in that it does not require phosphorylation (activation) by enzymes such as viral thymidine kinase. Certain strains of viruses are thymidine-kinase deficient, meaning that these viruses lack the enzyme needed to activate antiviral agents [Pg.529]

Adverse Effects. The primary problem associated with foscarnet is impaired renal function, including acute tubular necrosis. Hematologic disorders (anemia, granulocytopenia, leukopenia), gastrointestinal disturbances (cramps, nausea, vomiting), and CNS toxicity (confusion, dizziness) may also occur during foscarnet treatment. [Pg.529]

Check parathyroid hormone (PTH), vitamin D and precursors, magnesium, and phosphate levels ° Pharmacological causes of decreased ionized calcium may include excess infusions of citrate, EDTA, lactate, fluoride poisoning, foscarnet, cinacalcet, bisphosphates, or unrelated increase in serum phosphate or decrease in serum magnesium levels... [Pg.161]

Other drugs that are commonly implicated in causing ARF include acyclovir, adefovir, carboplatin, cidofovir, cisplatin, foscarnet, ganciclovir, indinavir, methotrexate, pentamidine, ritonavir, sulfinpyrazone, and tenofovir.45... [Pg.371]

Acyclovir 20 mg/kg IV every 8 hours (neonates) Alternative Therapy Foscarnet 120-200 mg/kg IV per day in divided doses every 8-12 hours neurotoxicity, phlebitis Nephrotoxicity, electrolyte imbalances, nausea/ vomiting, headache, penile ulceration, thrombophlebitis, seizures ... [Pg.1040]

Foscarnet, cidofovir, and trifuridine have been administered in acyclovir-resistant patients.30 These agents are usually reserved for use after other agents have failed because of their associated toxicities. [Pg.1170]

Foscarnet 40 mg/kg IV q8—12hours x 2-3 wkor until clinical resolution is attained Renal insufficiency, metabolic disturbances, hypophosphatemia... [Pg.1171]

Amphotericin B Azoles Nephrotoxins (e.g, aminoglycosides, cidofovir, cyclosporine, foscarnet, pentamidine) See Chap. 125 in Pharmacotherapy A Pathophysiologic Approach, seventh edition, page 1998. Additive adverse effects Monitor renal function... [Pg.396]

Foscarnet Pentamidine IV Increased risk of severe nephrotoxicity/hypocalcemia Monitor renal functiorVserum calcium... [Pg.396]

Ganciclovir intraocular implant plus valganddovir 900 mg once daily until immune recovery from ART (Al)° Ganciclovir 5 mg/kg IV every 12 hours or foscarnet 180 mg/kg/day in two or three divided doses IV for 21 to 28 days (Bll)... [Pg.459]

R. P. Iyer, J. H. Boal, L. R. Phillips, D. R. Thakker, W. Egan, Synthesis, Hydrolytic Behavior, and Anti-HIV Activity of Selected Acyloxyalkyl Esters of Trisodium Phosphonoformate (Foscarnet Sodium) , J. Pharm. Sci. 1994, 83, 1269- 1273. [Pg.604]

G. D. Kini, J. R. Beadle, K. A. Aldern, K. Y. Hostetler, Propanediol Phospholipid Prodrugs of Foscarnet (PFA) Synthesis and Structure-Antiviral Activity Relationships , in Abstracts of the 211th American Chemical Society National Meeting, Division of Medicinal Chemistry , New Orleans, LA, March 24-28, 1996, Abstract No. 172. [Pg.604]

Folic acid (Folvite) Mineral Fomepizole (Antizol) Antidote Foscarnet (Foscavir) Antiretroviral... [Pg.27]

Seizures related to alterations in plasma minerals and electrolytes have been associated with foscarnet treatment. Therefore, patients must be carefully monitored for such changes and their potential sequelae. Mineral and electrolyte supplementation may be required. [Pg.1736]

HSV infections Foscarnet is not a cure for HSV infections. While complete healing may occur, relapse occurs in most patients. [Pg.1736]

Foscarnet Dosing Guide Based on Ccr for Induction HSV Equivalent to... [Pg.1737]

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