Foscarnet sodium

R. P. Iyer, J. H. Boal, L. R. Phillips, D. R. Thakker, W. Egan, Synthesis, Hydrolytic Behavior, and Anti-HIV Activity of Selected Acyloxyalkyl Esters of Trisodium Phosphonoformate (Foscarnet Sodium) , J. Pharm. Sci. 1994, 83, 1269- 1273. [Pg.604]

Accidental exposure Accidental skin and eye contact with foscarnet sodium solution may cause local irritation and burning sensation. Flush the exposed area with water. Other CMV infections Safety and efficacy have not been established for the treatment of other CMV infections (eg, pneumonitis, gastroenteritis) congenital or neonatal CMV disease nonimmunocompromised individuals. [Pg.1739]

Foscarnet sodium is an pyrophosphate analogue. It inhibits viral DNA polymerase and reverse transcriptase. Its main indication is cytomegalovirus retinitis in AIDS patients which have contraindications for ganciclovir. [Pg.420]

Foscarnet sodium Induction—Normal Renal Function 60 mg/kg IV at a constant rate over a minimum of 1 hour every 8 hours for 2 to 3 weeks depending on clinical response c 5 S... [Pg.27]

Common Name Foscarnet sodium Foscarnetum natricum Trisodium phosphonoformate... [Pg.1711]

AMINOGLYCOSIDES FOSCARNET SODIUM Possible T nephrotoxicity Additive side-effect Monitor renal function closely... [Pg.512]

QUINOLONES FOSCARNET SODIUM Risk of seizures Unknown possibly additive side-effect Avoid combination in patients with past medical history of epilepsy. Consider an alternative antibiotic... [Pg.530]

PENTAMIDINE ISETIONATE (INTRAVENOUS) FOSCARNET SODIUM Risk of hypocalcaemia Unclear possibly additive hypocalcaemic effects Use extreme caution with intravenous pentamidine monitor serum calcium (correct before the start of treatment), renal function and signs of tetany closely. Stop one drug if necessaiy... [Pg.595]

LAMIVUDINE, TENOFOVIR, ZALCITABINE FOSCARNET SODIUM t adverse effects with tenofovir and possibly lamivudine and zalcitabine Uncertain possibly additive toxicity via competition for renal excretion Avoid if possible otherwise monitor FBC and renal function weekly... [Pg.608]

PROTEASE INHIBITORS ANTIVIRALS-FOSCARNET SODIUM 4 renal function when co-administered with ritonavir or saquinavir Uncertain possibly l renal excretion of fbscarnet Monitor renal function closely... [Pg.620]

ADEFOVIR DIPIVOXIL 1. ANTIBIOTICS -aminoglycosides, vancomycin 2. ANTICANCER AND IMMUNOMODULATING DRUGS - cidosporin, tacrolimus 3. ANTIFUNGALS-amphotericin, 4. ANTIPROTOZOALS-pentamidine 5. ANTIVIRALS - cidofovir, foscarnet sodium, tenofovir Possible t efficacy and side-effects Competition for renal excretion Monitor renal function weekly... [Pg.630]

FOSCARNET SODIUM ANTICANCER AND IMMUNOMODULATING DRUGS-CICLOSPORIN t risk of renal failure Additive nephrotoxic effects Monitor renal function... [Pg.631]

FOSCARNET SODIUM ADEFOVIR DIPIVOXIL Possible t efficacy and side-effects Competition for renal excretion Monitor renal function weekly... [Pg.632]

The sites at which anti-HIV drugs may. in principle, act, are dealt with in detail under a main heading (see ANTIVIRAL agents). In summary, currently, of the drugs actually in use, a number are reverse transcriptase (enzyme) inhibitors (RTIs). Examples of nucleoside RTIs include zidovudine, didanosine and zalcitabine. Some non-nucleoside RTIs include foscarnet sodium, nevirapine, carbovir and TIBO analogues (some of these are at trial stage only). [Pg.30]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...