Follicular hormones

Bastenie and Zylberszac, in a general article on the former subject, point out that colchicine (1) brings into mitosis all cells which are in karyo-kinetic inuninence but which normally would slowly and successively reach mitosis, and (2) stops them at this stage. This has made possible a technique which picks out cell multiplication and can be used for detecting many types of hormonal stimulation, e.g., the action of follicular hormone and other oestrogens. ... 

Common Name Estrone Foliculina Follicular hormone Folliculine ... 

SYNS ALTRAD BARDIOL DIHYDRO-FOLLICULAR HORMONE DIHYDROFOLLICULIN DIHYDROMENFORMON DIHYDROTHEELIN 3,17-P-DIHYDROXYESTRA-1,3,5(10)-TRIENE 3,17-p-DIHYDROXY-1,3,5(10)-ESTRATRIENE DIHYDROXY-ESTRIN 3,17-p-DIHYDROXYOESTRA-l,3,5-TRIENE ... 

What are Follicular Hormones Classify them and describe the synthesis of one potent drug from each class. 

Butenandt A, The female sexual hormone. XI. Constitution of the follicular hormone. 2. The degree of saturation and Bie aromatic character of the follicular hormone, Z. Physiol. Chem., 223,147-168 (1934). NB Historical value only. Gave K = 0.44 x 10 , i.e.,... 

Lipid droplets in the cells of the theca interna resembling those in the interstitial cells and luteum cells were pictured by Mulon (1912), Long and Evans (1922), Yamauchi (1926), and others. In 1922 Mulon maintained that secretions of the follicle were responsible for the phenomena of estrus in lower mammals, and Bouin, in commenting on this paper, made the suggestion that the theca interna might secrete the follicular hormone. Subsequent studies supporting this hypothesis are to be found in the review by Corner (1938). 

The Follicular Hormone.— This hormone occurs in the urine of pregnancy in four forms (1) cestrone, Cj8H2g02, (2) cestriol,... 

Follicular hormones CEstrone. GEstriol. Fquilin. Fipiilenin. (Estrus control. 

Estradiol is the actual ovarian follicular hormone. It is a colourless steroid, slightly soluble in water, but freely soluble in organic solvents. Chemically, it is the 3 4-dihydroxy derivative of oestrane, or 13-methyl cydo-pentano phenanthrene, the mono-methylated steroid nucleus which occurs in all the natural oestrogens (p. 172). (Estrone and oestiiol represent various oxidation... 

An exception is made by the follicular hormone estradiol, which appears to be formed from cholesterol (cf. Chapt. XIV-6). 

A number of hormones including the adrenocortical hormones, are steroids (see Table XVIII). The chemistry of steroids has already been discussed briefly. With the exception of the follicular hormone estrone, all steroid hormones have an a, 3-unsaturated keto group in ring A. 

Physiological Effects. The follicular hormone (estrogen) is responsible primarily for the regular course of the genital cycles, which are the estrus cycles (assay procedures on laboratory animals) or the menstrual cycles (in man and monkeys). Estrone causes uterine mucosa to proliferate. During the cycle it acts in conjunction with progesterone and the hypophyseal hormones (cf. also Section 11.)... 

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