Foldamers

Goodman, C. M., Choi, S.. Shandler, S. and DeGrado, W. R, Foldamers as versatile frameworks for the design and evolution of fnnction . Nature Chem. Biol. 2007, 3, 252-262. 

---

Enhance the Diversity of Secondary Structure in Peptoid Foldamers... 

Constrained y9 -amino acids in which the C(2)-C(3) bond is part of a small ring (5- and 6-membered rings) have been used extensively by GeUman (tra s-2-amino-cycloalkanecarboxyhc acids 33—42) and others (43 and 44) for the preparation of stable y9-peptide foldamers (Fig. 2.7). 

The temperature measurements in range from —40 to 23 °C revealed the presence of conformational equilibrium between conformers of the opposite helicity (M- and P-helix). The barrier of 13 kcal/mol of the chemical exchange was estimated. It was shown that peripheral stereocenters control the absolute sense of helicity in the foldamers studied.103... 

HillDJ.Mio MJ, Prince RB, Hughes TS, Moore JS (2001) Chem Rev 101 3893-4012 A field guide to foldamers... 

Current efforts toward oPE foldamers have focused on developing a computational model that will allow useful predictions of structure. This model was validated by comparing computational results to previously published experimental results [101]. For both crystal structure data and methyl- and hydrogen-series mPEs [25,57], the MMFF molecular mechanics system [102,103]... 

Haley MM, Pak JJ, Brand SC (1999) Top Curr Chem 201 81 HOger S (1999) J Polym Sci A Polym Chem 37 2685 Bunz UHF, Rubin Y, Tobe Y (1999) Chem Soc Rev 28 107 Faust R (1998) Angew Chem Int Ed 37 2825 Moore JS (1997) Acc Chem Res 30 402 Zhao D, Moore JS (2003) Chem Commun 807 Nelson JC,Saven JG,Moore JS,Wolynes PG (1997) Science 277 1793 Shetty AS, Zhang J, Moore JS (1996) J Am Chem Soc 118 1019 Prince RB,Saven JG,Wolynes PG,Moore JS (1999) J Am Chem Soc 121 3114 Hill DJ, Moore JS (2002) Proc Natl Acad Sci USA 99 5053 Cantor CR, Schimmel PR (1980) Biophysical chemistry. Freeman, San Francisco Prince RB (2000) Phenylene ethynylene foldamers cooperative conformational transition, twist sense bias, molecular recognition properties, and solid-state organization. PhD thesis. University of Illinois at Urbana-Champaign... 

Cuhherley MS, Iverson BL. Models of higher-order structure foldamers and heyond. Curr Opin Chem Biol 2001 5 650 653. 

Li X, Yang D. Peptides of aminoxy acids as foldamers. Chem Commun 2006 3367-3379. 

Licini G, Prins LJ, Scrimin P. Oligopeptide foldamers from stmeture to function. Eur J Org Chem 2005 969-977. 

Sanford AR, Yamato K, Yang XW, Yuan LH, Han YH, Gong B. Well-defined secondary structures information-storing molecular duplexes and helical foldamers based on unnatural peptide backbones. Eur J Biochem 2004 271 1416-1425. 

Yang XW, Martinovic S, Smith RD, Gong B. Duplex foldamers from assembly-induced folding. J Am Chem Soc 2003 125 9932-9933. 

The building of a cavity around the guest is an extension of induced fit concept. This is the case with hexokinase enzyme [ 13b] and foldamers [ 13c] that wrap themselves around the guest. 

A. Vasella Oligoribonucleotide foldamers with a novel architecture... 

Proteins and Foldamers Single Molecule Self-Assembly... 

Figure 10.5 (a) solution structure of the tailbiter foldamer (10.1) (reproduced by permission of... 

---