Abiotic foldamers

V. Single-Stranded Abiotic Foldamers 3944 1. Zipper Duplexes 3986... 

These architectures are more commonly referred to as artificial receptors while at the same time fitting under the categorization of foldamer duplexes since they adopt their unique conformations through these noncovalent interactions and form similar architectures as described in the previous two sections on multistranded abiotic foldamers. 

Inspired by the structural and functional diversity of biomacromolecules, synthetic chemists have for many years been attempting to design nonbiological chain molecules that fold into stable, well-defined conformations. Such non-natural molecules, which are commonly referred to as foldamers [1, 2], can be broadly allocated to two categories bio-like (peptidomimetics) and abiotic. Bio-Uke foldamers chemically resemble proteins, while abiotic foldamers are composed of un-natural repeat units. 

In this chapter, whilst attention is focused on the synthesis aspect of foldamer research, discussions are restricted to the synthesis of abiotic foldamers that adopt only a well-defined, single-helical stracture in solution." A quick glance at the... 

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