Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Focus - Ibuprofen

To get around this problem, pharmaceutical companies attempt to devise methods of enantioselective synthesis, which allow them to prepare only a single enantiomer rather than a racemic mixture. Viable methods have already been developed for the preparation of (5)-ibuprofen, which is now being marketed in Europe. We ll look further into enantioselective synthesis in the Chapter 19 Focus On. [Pg.322]

NSA1D (Chapter 15 Focus On) A nonsteroidal antiinflammatory drug, such as aspirin or ibuprofen. [Pg.1246]

Previous treatment has focused on the use of topical products. Initially, these were over-the-counter products which provided relief but which also caused irritation at times. The patient took paracetamol and ibuprofen to help manage irritation, pain and swelling associated with psoriasis and the topical products. [Pg.301]

Solubilisation by surface-active agents is discussed in Chapter 6. Alternatives to micellar solubilisation (or solubilisation in vesicles) include the use of the cyclodextrin family. When the first edition of this book was published in 1981 (and a diagram of a cyclo-dextrin-dmg complex was used to adorn the cover), the use of cyclodextrins was in its infancy. Attention was then focused around a-, P- and yavailable commercially for pharmaceutical use. Ten per cent of this cyclodextrin can enhance the solubility of betamethasone 118 times, of diazepam 21 times and of ibuprofen 55 times. [Pg.158]

Vinyl Aromatics To date, most academic efforts have focused on AHF of vinyl arenes to get access to enantiomerically pure 2-aryl propionic acids (Figure 4.7). Several of these compounds constitute a class of nonsteroidal inflammatory drugs, such as (5)-naproxen, (5)-ibuprofen, (f )-flurbiprofen, and (5)-ketoprofen, also collected under the name profens [19]. [Pg.334]

A new approach in the 1990s was to use supercritical fluid technology to produce uniform particles to replace crystallization. Even though super critical fluids were discovered over 100 years ago, and the commercial plant was built over 20 years ago in the United States, it is only now that the technology is used for a number of pharmaceutical applications (2-5), so as to produce aspirin, caffeine, ibuprofen, acetaminophen, etc. One of the major areas on which the research and development of supercritical fluids is focused is particle design. There are different concepts such as rapid expansion of supercritical solution, gas antisolvent recrystallization, and supercritical antisolvent to generate particles, microspheres, microcapsules, liposomes, or other dispersed materials. [Pg.2]

Cosolvent effect on aqueous solubility at different temperatures have been reported mostly in pharmaceutical studies, which report the thermodynamics of drug dissolution for ibuprofen, naproxen, oxolinic acid, probenecid, phenacetin, etc. in water mixed with cosolvents such as ethanol, propylene glycol, or dioxane. " " " Few such studies have been done in environmental research, although many have focused on either the effect of cosolvents at a specific temperature or the effect of temperature on solubility in water without involving cosolvents. Due to the needs of environmental remediation, cosolvent effects on the sorption and Henry s law constant under different temperatures have been reported. " ... [Pg.206]


See other pages where Focus - Ibuprofen is mentioned: [Pg.1701]    [Pg.1701]    [Pg.1701]    [Pg.1701]    [Pg.1701]    [Pg.1701]    [Pg.17]    [Pg.169]    [Pg.54]    [Pg.58]    [Pg.208]    [Pg.236]    [Pg.382]    [Pg.179]    [Pg.375]    [Pg.426]    [Pg.727]    [Pg.659]    [Pg.118]    [Pg.286]    [Pg.556]    [Pg.792]    [Pg.362]    [Pg.91]    [Pg.647]    [Pg.396]    [Pg.39]    [Pg.412]    [Pg.127]    [Pg.2835]    [Pg.662]   


SEARCH



Ibuprofen

© 2024 chempedia.info