Flurbiprofen formulations

A transdermal flurbiprofen formulation has been prepared from flubiprofen span 60, cholesterol, DCP (46 50 4) niosomes incorporated within an HPMC semi-solid base containing 10 % glycerin [155]. The in vitro characterization of the formulation is not given, however this formulation was evaluated in a rat inflammation model. 

Flurbiprofen is also available in a topical ophthalmic formulation for inhibition of intraoperative miosis. Flurbiprofen intravenously is effective for perioperative analgesia in minor ear, neck, and nose surgery and in lozenge form for sore throat. 

Flurbiprofen Park and Kim (1999) Solubilization in emulsion formulation reduces volume required for parenteral delivery... 

Three EPMEs based on carbon paste impregnated with different maltodextrins (DE 4.0-7.0 (I), 13-17 (II), 16.5-19.5 (III)) were proposed as chiral selectors for the assay of S-flurbiprofen raw materials and from its pharmaceutical formulation, Froben 100 tablets [38]. The best response and enantioselectivity were obtained when maltodextrin with the lowest DE was used for the electrode design. The three EPMEs showed very low detection limits. 

The efficacy of flurbiprofen at dosages of 200-400 mg/d is comparable to that of aspirin and other NSAIDs in clinical trials for patients with rheumatoid arthritis, ankylosing spondylitis, gout, and osteoarthritis. It is also available in a topical ophthalmic formulation for inhibition of intraoperative miosis. Flurbiprofen intravenously has been found to be effective for perioperative analgesia in minor ear, neck, and nose surgery and in lozenge form for sore throat. 

Jones, D. S., Irwin, C. R., Woolfson, A. D., Djokic, J., and Adams, V. (1999), Physicochemical characterization and preliminary in vivo efficacy of bioadhesive, semisolid formulations containing flurbiprofen for the treatment of gingivitis, J. Pharm. Sci., 88, 592-598. 

Flurbiprofen, 100 mg three times daily, is a well-established first-line NSAID providing there is no evidence of vascular closure or scleral destruction on biomicroscopy. Flurbiprofen should provide pain relief within 2 days and improvement in clinical signs within 1 week. Indomethacin SR fiarmulation, 75 mg twice daily, is a well-established second-choice drug when flurbiprofen is not effective but has also been used as first line. NSAIDs that have shown efficacy and are now available in over-the-counter formulations include naproxen, 500 mg twice daily, and ibuprofen, 600 mg four times daily. If a simplified dosing schedule is a consideration, then pirox-icam, 20 mg/day, may be considered. Once effective control is established, a lower maintenance dose may suffice until the scleritis enters remission. To reduce the risk of gastrointestinal side effects, patients should be instructed to take NSAIDs with food or antacids. 

Innes EH. Efficacy and tolerance of flurbiprofen in the elderly using hquid and tablet formulations. Curr Med Res Opin 1977 5(l) 122-6. 

El Assasy AH, Foda NH, Badawi SS, Abd-El-Rehim RT. Formulation of flurbiprofen suppositories. Egyptian J Pharm Sci 1995 36(l-6) 31-53. 

Magnesium hydroxide increased the initial absorption of ibuprofen and flurbiprofen, but had no effect on ketoprofen. Unexpectedly, a pharmacodynamic study showed increased gastric erosions when ibuprofen was formulated with magnesium hydroxide. 

Pargal A, KeUcar MG, Nayak PI The effect of food on the bioavailabUily of ibiqrrofen and flurbiprofen from sustained release formulation BiopharmDrugDispos( 996) 17,511-19. 

Shahzad MK, Ubaid M, Raza M, Murtaza G. The formulation of flurbiprofen loaded microspheres using hydroxypropylmethyceUulose and ethylcellulose. Advances in Clinical and Experimental Medicine Official Organ Wroclaw Medical University. March-April 2013 22(2) 177-183. PubMed PMID 23709373. 

Solid lipid nanoparticles have been used for topical application for various dmgs, such as tropolide, imidazole antifungals, anticancers, vitamin A, isotretinoin, ketoconazole, DNA, flurbiprofen, and glucocorticoids (Choi et al., 2006) and also in various formulations of sunscreens and UV blockers (Wissing and Muller, 2001). 

Details are given of the preparation of nanoparticle suspensions of ethyl acrylate-methyl methacrylate copolymers and loaded with flurbiprofen. The availability of the drug at an intra-ocular level for the prevention of the myosis induced during extracapsular cataract surgery was investigated. Nanosuspensions were prepared by a quasi-emulsion solvent diffusion technique using different formulation parameters. 34 refs. 

Shah SN, Asghar S, Choudhry MA, Akash MS, ur Rehman N, Baksh S. Formulation and evaluation of natural gum-based sustained release matrix tablets of flurbiprofen using response surface methodology. Drug Dev Ind Pharm. 35 (12) 1470-1478,2009. 

---