Fluoroacetate respiratory effects

The vapor irritates the eyes and respiratory system. The liquid burns the eyes and quickly penetrates the skin to cause deep-seated burns. Assumed to cause severe burning and damage if taken by mouth. There is no reported toxic effect due to the presence of fluorine, as in the case of highly toxic fluoroacetic acid. Avoid breathing vapor. Prevent contact with skin and eyes.1... 

Compound 1080 is absorbed from the gastrointestinal tract, respiratory tract, mucous membranes, and wounds (Holstege et al, 2007). Different routes of exposure do not have a remarkable effect on toxicity. The mechanism of action for SMFA is blockage of the Krebs cycle. Metabolic activation by the formation of fluorocitrate is required a process known as lethal synthesis. Fluoroacetate is converted to fluoroacetyl-CoA and then converted by the enzyme... 

Acute fluoroacetate poisoning can result in nausea, vomiting, cardiac arrhythmia, cyanosis, generalized convulsions, hypotension, and death from ventricular fibrillation or respiratory failure. Residual effects are uncommon if the patient survives the acute toxicity. 

Insecticides, rat poisons sodium fluoride, sodium fluoroacetate crystalline. Block citric acid cycle by forming fluorocitrate, which inhibits the next enzyme in the cycle. Effects vomiting, convulsions, coma, respiratory and cardiac arrest. Deadly at ca 5 mg/kg oral. 

By studying the effect of Bryophyllum leaf section thickness on respiration, Kinraide and Behan (1975) noted that as sections decreased in size, O2 uptake increased, and organic acid accumulation was depressed. The specific inhibitors of the citric acid cycle, malonate and fluoroacetate, inhibited the increased oxygen consumption and restored acid accumulation in the thin, 1-mm leaf sections. Other respiratory inhibitors, not specific for the citric acid cycle, did not restore acid accumulation. Hence, they concluded that respiration competes with acid synthesis. 

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