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Fluoro-methylprednisolone

I, 4-dien-3,20-dione (27.1.51), or simply 9a-fluoro-16a-methylprednisolone. The distinctive characteristic of dexamethasone is the presence of a fluorine atom at C, of the steroid ring. [Pg.357]

Sample extraction and deproteinization is usually accomplished with nonpolar organic solvents at a specified pH. Organic solvents such as chloroform for the determination of cortisol in milk (529) dichloromethane/hexane (4 1) for the determination of free cortisol and its 21-acetate in milk (530) ethyl acetate for the determination of prednisolone, fluoroprednisolone, triamcinolone, and betamethasone in animal tissues (531) methylprednisolone in milk (532) fluoro-prednisolone in milk (533) and dexamethasone in milk (534) ethyl acetate in... [Pg.1105]

Dexamethasone 21-acetate [9-a-fluoro-16-a-methylprednisolone-21-acetate) [1177-87-3] M 434.5, m 215-225°, 229-231°, [a]2D5 +77.6° (c 1, dioxane), +73 (c 1, CHCI3). Purified on neutral Al203 using CHCI3 as eluent, fraction evaporated, and recrystd from CHCI3. UV has A,max at 239nm. [Oliveto et al. JACS 80 4431 1958]. [Pg.165]

On the hypothesis that the side chain could perhaps be stabilized against such metabolic inactivation by an appropriately placed but otherwise chemically inert substituent, some analogues of cortisone containing a 16a-methyl group were synthesized by Arth et al. [20] in the expectation that the 16a-methyl substituent would enhance potency by protecting the 20-ketone from metabolism. Ultimately, these authors prepared 9-fluoro-16a-methylprednisolone which was the first derivative of fluorocortisol with markedly increased anti-inflammatory activity that was devoid of mineralocorticoid activity. This latter fact supports the concept that it is the presence of 16a-substituents that prevents binding to the mineralocorticoid receptor. Dexamethasone has become Merck s principal marketed anti-inflammatory steroid. [Pg.426]

Dexamethasone (= 9a-Fluoro-16ot-methylprednisolone)] (glucocorticoid steroid) [Prednisolone (= A1-Dehydrocortisol)] (glucocorticoid, steroid)... [Pg.459]

Synonym. 9a-Fluoro-16)3-methylprednisolone 17-Valerate Proprietary Names. Bedermin Betacort Betaderm Betnelan-V Betnesol-V Betneval Betnovat(e) Bextasol Celestoderm(-V) Celestone-V Dermovaleas Ecoval Valisone. [Pg.393]

Synonyms. Desamethasone 9a-Fluoro-16a-methylprednisolone. Proprietary Names. Aeroseb-Dex Decaderm Decadron (elixir and tablets) Decalix Decaspray Dexacortisyl Dexalocal Dexasone (tablets) Dexone Dezone (tablets) Fortecortin (tablets) Hexadrol (tablets) Maxidex Millicorten Miral Oradexon (tablets). It is an ingredient of Maxitrol. [Pg.518]

Synonym. Sodium 9a-Fluoro-16a-methylprednisolone 21-Phosphate Proprietary Names. Dalaron Decadron (injection) Decasone Dexacen-4 Dexasone (injection) Dezone (injection) Fortecortin (injection) Hexadrol (injection) Novadex Oradexon (injection) Savacort-D Turbinaire Decadron. [Pg.519]

Fluoromethylmethylsulphinylbenzylideneindenylacetic acid, 981 Fluoro-16a-methylprednisolone, 518 Fluoro-16 -methylprednisolone, 392 Fluoromethylprednisolone acetate, 852 Fluoromethylprednisolone valerate, 393 Fluorophenylaceturic acid, 648... [Pg.1372]

METHYLPIPERIDINO)BUTYROPHENONE HYDROCHLORIDE see FKIOOO 9-a-FLUORO-l 6-a-METHYLPREDNISOLONE see... [Pg.1697]

Synonym 9a-Fluoro-16/J-methylprednisolone Source Dean, J. R. Kane, M. ... [Pg.95]

The same general scheme for introducing the 9a-fluoro substituent is applicable to corticoids that feature a 6a-methyl group. 6a-Methylprednisolone (9-4) provides the starting material for the synthesis of fluorometholone (23-5) (Scheme 7.23). The standard sequence is again used to introduce the 9a-fluoro function (9-4 23-1). The only readily accessible hydroxyl at C21 is next converted to the mesylate 23-3 by acylation with methanesulfonyl chloride. Treatment of that intermediate with sodium iodide replaces the mesylate to afford the more readily reducible 21-iodo... [Pg.113]

Names synonyms BETAMETHASONE 9a fluoro> 16 methylprednisolone 16/f-methyl> 11 17a 21 -trihydroxy 9 fluoro-1.4-pregnadiene-3.20-dione. BETAMETHASONE ACETATE 9a-fluoro-16/9-methylprednisolone-2) -acetate. BETAMETHASONE DlSODtUM PHOSPHATE 9a-fluoro-16 -methylpredni olone-21 -disodium phosphate. [Pg.2630]

The synthesis of 9a-fluoro-18-methylprednisolone (282), a representative of still another new class of corticosteroids, has been described.The sequence, shown in Scheme 11, used the known radical-induced 1,4-rearrangement of... [Pg.461]

Hydrocortisone is extensively bound to the plasma proteins, primarily to transcortin (corticosteroid-binding globulin), with only 5 to 10% of plasma hydrocortisone unbound. Prednisolone and methylprednisolone, but not the 9a-fluoro analogues betamethasone, dexamethasone, or triamcinolone, have a high affinity for transcortin and, thus, compete with hydrocortisone for this binding protein. The 9a-halo analogues bind primarily to albumin. [Pg.1324]

Dexamethasone (I) is 9a-fluoro-llS,17a,21-trihy-droxy-16a-methylpregna-l,4-dlene-3,20-dione. Other names for Che compound Include 9a-fluoro-16a-methylprednisolone and 16a-methyl-9a-fluoroprednisolone. The Merck Index lists three other chemical names for dexamethasone. Proprietary names for dexamethasone include Decadron, Dexacortisyl, Oradexon, Hexadrol and Deronll. A number of others are listed in the monograph for dexamethasone in the Merck Index. ... [Pg.165]

Many synthetic corticoids were introduced following the discovery of triamcinolone. These include triamcinolone 16,17-acetonide, 6o -methylprednisolone, 16a -methyl-9o -fluoroprednisolone (dexamethasone), 16 -methyl-9a(-fluoroprednisolone (betamethasone), 6o -fluoro-16a-methylprednisolone (paramethasone), 16-methylene-prednisolone, and 6a, 9a -dlfluoro-16a-hydroxyprednisolone 16,17-acetonide (fluocino-lone acetonide). Microbiology played no essential role in their discovery, although in some cases microbiological technology has been employed to advantage in their manufacture. [Pg.9]

Synonyms 9a-fluoro-16(3-methyl-ll(3,17a,21-trihydroxy-l,4-pregnadiene-3,20-dione-17-valerate 9a-fiioro-16 p-methylprednisolone- 17-valerate ... [Pg.38]

C22H29FO5, 9a-Fluoro-6a-methylprednisolone, 40B, 495 C2 2H2 9KOi, Potassium 1 7 -hydroxy-3-oxo-4,6-pregnadiene-21 -carboxy-late, 42B, 402... [Pg.259]

Triton WR 1339 and Tween 80 have both been used in formulations of adrenal cortical hormone preparations for the eye [161,162]. It was found that the solubility of prednisolone, methylprednisolone, and fluoromethalone in aqueous solutions of Triton WR 1339 was linearly dependent on the detergent concentration. The structures of the compounds are given below their solubility behaviour in Table 6.19. From this it can be seen that there are striking differences in the amounts solubilized, and it is obvious that the fluoro-derivative is more difficult to solubilize than the others mentioned. [Pg.335]

See other pages where Fluoro-methylprednisolone is mentioned: [Pg.187]    [Pg.187]    [Pg.358]    [Pg.1298]    [Pg.165]    [Pg.165]    [Pg.165]    [Pg.101]    [Pg.102]    [Pg.102]    [Pg.270]    [Pg.1457]    [Pg.852]    [Pg.101]    [Pg.102]    [Pg.881]    [Pg.943]    [Pg.751]    [Pg.754]    [Pg.654]    [Pg.463]    [Pg.200]    [Pg.848]    [Pg.848]    [Pg.200]    [Pg.1537]   
See also in sourсe #XX -- [ Pg.11 ]



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