Fluorine-18 deoxyglucose

Tamaki N, Yonekura Y, Yamashita K, Saji H, Magata Y, Senda M et al. Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting. Am J Cardiol 1989 64 860-865... 

Tamaki N, Kawamoto M, Takahashi N, Yonekura Y, Magata Y, Nohara R et al. Prognostic value of an increase in fluorine-18 deoxyglucose uptake in patients with myocardial infarction comparison with stress thallium imaging. J Am Coll Cardiol 1993 22 1621-1627... 

During his visit to Johns Hopkins in 1965 for the NIH site visit of our cyclotron proposal, Alfred Wolf, a chemist in charge of the cyclotron at the Brookhaven National Laboratory (BNL), saw the potential value of cyclotron-produced radionuclides in biomedical research. He and his colleagues, including Joanna Fowler, subsequently developed a large number of radioactive tracers, including fluorine-18 deoxyglucose (FDG),... 

Michael Phelps, Chugani and colleagues at the University of California at Los Angeles, carried out PET studies of brain metabolism with fluorine-18 deoxyglucose (FDG) in growing children. Phelps later told writer Joseph Dumit ... 

Sokoloff examined the kinetics of carbon-14 deoxglucose metabolism in the brain of animals. In 1982, Shlomo Levy began producing F from oxygen-18, using the reaction (p,n) F. In 1986, Hamacher synthesized F fluoride rather than F2 gas. These advances in the production of F-18 led to the important subsequent development of fluorine-18 deoxyglucose (FDG). 

The development of fluorine-18 deoxyglucose by Itoh, Wolf and colleagues made it possible to extend the autoradiographic studies of Sokoloff to living human beings. When Sokoloff injected C-14 deoxyglucose into animals with one eye closed, there were... 

Langenhoff BS, Oyen WJ, Jager GJ, Strijk SP, Wobbes T, Corstens FH, Ruers TJ (2002) Efficacy of fluorine-18-deoxyglucose positron emission tomography in detecting tumor recurrence after local ablative therapy for liver metastases a prospective study. J Clin Oncol 20 4453-4458... 

Brudin LH, Vahnd SO, Rhodes CG, Pantin CF, Sweatman M, Jones T, Hughes JM. Fluorine-18 deoxyglucose uptake in sarcoidosis measured with positron emission tomography. Eur J Nucl Med 1994 21 297-305. 

Deoxyglucose labeled with fluorine-18 is commonly used in PET scans to locate tumors. Fluorine-18 has a half-life of 109 min. How long will it take for the level of fluorine-18 in the body to drop to 10% of its initial value ... 

F-2-fluoro-2-deoxyglucose (2-FDG) is normally produced in places where a cyclotron is locally available. Its molecular formula is CsHn FOs with molecular weight of 181.3 daltons. 18F-2-FDG can be produced by electrophilic substitution with 18F-fluorine gas or nucleophilic displacement with 18F-fluoride ions. The radiochemical yield is low with the electrophilic substitution, so the nucleophilic displacement reaction has become the method of choice for 18F-FDG synthesis. Deoxyglucose is labeled with 18F by nucleophilic displacement reaction of an acetylated sugar derivative followed by hydrolysis (Hamacher et al, 1986). In nucleophilic substitution, a fluoride ion reacts to fluorinate the sugar derivative. A solution of 1,3,4,6-tetra-O-acetyl-2-0-trifluoromethane-sulfonyl-/ -D-mannopyranose in anhydrous acetonitrile is added to a dry residue of 18F-fluoride containing aminopolyether (Kryptofix 2.2.2) and potassium carbonate (Fig. 8.1). Kryptofix 2.2.2 is used as a catalyst to enhance the reactivity of the fluoride ions. The mixture is heated... 

Jacob R, Welkoborsky HJ, Mann WJ, Jauch M, Amadee R. [Fluorine-18]fluoro-deoxyglucose positron emission tomography, DNA ploid and growth fraction in squamous-cell carcinomas of the head and neck. ORL J Otorhinolaryngol Relat... 

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