Flavonoid pathway, metabolic engineering

The examples discussed here show that for two secondary metabolite pathways, metabolic engineering using transcription factors was successful. Modification of the phenylpropanoid/flavonoid pathway made use of the tissue-specific MYB... 

Flavonoids are a group of secondary plant metabolites. These compounds can be used as antioxidants or antiviral, antibacterial, and anticancer drugs. Many flavonoid biosynthetic pathways are known, and a wide array of flavonoid compounds from 5. cerevisiae are expected to be produced by metabolic engineering in the near future. 

Biosynthetic pathway flavonoids metabolic engineering microbial factory natural products novel flavonoids production and biotransformation of flavonoids proteomics synthetic biology... 

Besides flavonoids and other natural products, other unnatural compounds with significant titer are alternatively synthesized from glucose in E. coli through de novo design and development of novel metabolic pathway petrochemicals [62]. Thus, metabolic engineering and use of E. coli as a microbial factory has extensively attracted interest in the development of a novel system for modification and efficient production of highly useful compounds. 

Trantas E, Panopoulos N, Ververidis F (2009) Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces-cerevisiae. MetabEng 11 355-366. doi 10.1016/j.ymben.2009.07.004... 

Leonard E, Lim K-H, Saw P-N, Koffas MAG. 2007a. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. App. Env Microb 73 3877-3886. 

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