Tumors, flavonoid cytotoxic effects against

There is also a need to assess the role of the colonic microflora in the overall bioavailability and potential bioactivity of dietary flavonoids. The amoxmt of absorption of colonic metabolites is unclear at this time, and there is growing interest in the potential effects of the phenolic acids and their derivatives as potentially beneficial agents. For example, thehumanintestinalbacteriametabolites of rutin and quercetin, 3,4-dihydroxyphenylacetic acid, and 4-hydroxyl-phenyl-acetic acid have been shown to possess more effective antiplatelet aggregation activity than ratin and quercetin [107]. Furthermore, 2,4,6-trihydroxybenzaldehyde and quercetin were more effective than rutin in their cytotoxicity against tumor cell lines. The effects the phenolics themselves have on the microflora are an emerging field, and it is possible that a flavonoid-induced change in the rich colonic bacterial population may have an influence on the overall health of the individual. 

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