Fish allergens

Parvalbumin was found to be a major fish allergen in approximately 70% of fish allergies, mediated by parvalbumin IgE antibodies, leading to respiratory and gastrointestinal symptoms. Parvalbumin also became of interest because of its potential use in gene therapy to correct cardiomyopathy. 

Flamada, Y., Nagashima, Y., and Shiomi, K. (2001). Identification of collagen as a new fish allergen. Biosci. Biotechnol. Biochem. 65, 285-291. 

Untersmayr, E., Szalai, K., Riemer, A.B., Hernmer, W., Swoboda, I., Hantusch, B. et al. 2006. Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen. Mol Immunol 43(9) 1454—1461. 

Cross-Reactivity of Fish Allergens Interspecies Cross-Reactivity.227... 

CHANGES IN IMMUNOREACTIVITY AND ALLERGENICITY OF FISH ALLERGENS DURING TECHNOLOGICAL PROCESSES... 

Elsayed, S. and Apold, J. 1983. Immunochemical analysis of cod fish allergen M Location of the immunoglobulin binding sites as demonstrated by the native and synthetic peptides. Allergy 38 449 159. 

The major allergens responsible for ingestion-related allergic reactions due to crustaceans are tropomyosins, while mollusks seem to contain in addition to tropomyosin, other less well-characterized allergens (Table 9.4). It is to be noted that crustacean and mollusk allergens do not cross-react with fish allergens as these are mostly parvalbumins (further characterized in a different chapter). 

Bemhiesel-Broadbent J, Scanlon SM, Sampson H (1992b). Fish hypersensitivity II. CUnical relevance of altered fish allergenicity caused by various preparation methods. J. Allergy Clin. Immunol, 90 622-629. 

Bugajska-Schretter A, Elfman L, Fuchs T, et al. (1998). Parvalbumin, a cross-reactive fish allergen, contains IgE-binding epitopes sensitive to periodate treatment and Ca depletion. J. Allergy Clin. Immunol, 101 67-74. 

Swoboda I, Bugajska-Schretter A, Verdino P, et al. (2002). Recombinant carp parvalbumin, the major cross-reactive fish allergen a tool for diagnosis and therapy of fish allergy. J. Immunol, 168 4576 584. 

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