Film coating techniques

Stearic acid has been reported to cause pitting in the film coating of tablets coated using an aqueous film-coating technique the pitting was found to be a function of the melting point of the stearic acid. ... 

V. Coletta, H. Rubin, Wiirster coated aspirin I Film-coating technique. Pharml Sci, 53 953-955,1964. 

MicrocrystalUne cellulose (MCC) is mainly used in the pharmaceutical industry as a diluent/binder in tablets for both granulation and direct compression processes. Treating high quality cellulose with hydrochloric acid to the desired level yields purified miCTocrystalline cellulose which is a partially depolymerized cellulose [21]. Membrane controlled systans or monolithic matrix drag delivery systems obtained from cellulose derivatives provide controlled release of drags. Film coating techniques are employed for the manufacture of membrane controlled... 

Analytical separations may be classified in three ways by the physical state of the mobile phase and stationary phase by the method of contact between the mobile phase and stationary phase or by the chemical or physical mechanism responsible for separating the sample s constituents. The mobile phase is usually a liquid or a gas, and the stationary phase, when present, is a solid or a liquid film coated on a solid surface. Chromatographic techniques are often named by listing the type of mobile phase, followed by the type of stationary phase. Thus, in gas-liquid chromatography the mobile phase is a gas and the stationary phase is a liquid. If only one phase is indicated, as in gas chromatography, it is assumed to be the mobile phase. 

Acoustic Wave Sensors. Another emerging physical transduction technique involves the use of acoustic waves to detect the accumulation of species in or on a chemically sensitive film. This technique originated with the use of quartz resonators excited into thickness-shear resonance to monitor vacuum deposition of metals (11). The device is operated in an oscillator configuration. Changes in resonant frequency are simply related to the areal mass density accumulated on the crystal face. These sensors, often referred to as quartz crystal microbalances (QCMs), have been coated with chemically sensitive films to produce gas and vapor detectors (12), and have been operated in solution as Hquid-phase microbalances (13). A dual QCM that has one smooth surface and one textured surface can be used to measure both the density and viscosity of many Hquids in real time (14). 

Polyacetylenes. The first report of the synthesis of a strong, flexible, free-standing film of the simplest conjugated polymer, polyacetylene [26571-64-2] (CH), was made in 1974 (16). The process, known as the Shirakawa technique, involves polymerization of acetylene on a thin-film coating of a heterogeneous Ziegler-Natta initiator system in a glass reactor, as shown in equation 1. 

Raman spectroscopy is a very convenient technique for the identification of crystalline or molecular phases, for obtaining structural information on noncrystalline solids, for identifying molecular species in aqueous solutions, and for characterizing solid—liquid interfaces. Backscattering geometries, especially with microfocus instruments, allow films, coatings, and surfaces to be easily measured. Ambient atmospheres can be used and no special sample preparation is needed. 

The US Air Force has studied the encapsulation of liq monoproplnts such as alkyl nitrates in polymer films to form small spheres much like ball powder for use as gun proplnts (Refs 6, 8 9). Suspension coating techniques were used, and microcapsules were made with gelatin,... 

The rqjroducibility of polymer film formation is greatly improved by the spin coating technique where the polymer solution is applied by a microsyringe onto the center of a rapidly rotated disk electrode Rather thick films can be produced by repeated application of small volumes of stock solution. A thorough discussion and detailed experimental description of a reliable spin coating procedure was given recently... 

In this chapter, a brief introduction will be given mainly to the DEC, CNx, multilayer films and nano-composite coatings. Detailed and comprehensive introduction of the conventional thin solid coating technique is not the objective of this chapter. Readers are referred to relevant publications to attain the knowledge in this area. 

Solid phase extraction (SPE) is a very simple, rapid and reproducible cleanup technique that is now widely accepted as an alternative to the time-consuming liquid-liquid extractions. Additionally, SPE uses relatively small volumes of solvents, and is easy to automate. It is available in a number of different formats, including cartridges, disks, loose material, well plates or SPME using film-coated capillaries. SPE can be considered as an extraction technique when used for isolation and concentration or a cleanup technique when used to remove co-extractives from solvent extracts. The use of SPE for cleanup is discussed later. 

In a four-part article, Porter [130] provided a comprehensive review of tablet coating technology, with emphasis on contemporary practice. More specifically, a recent review [131] discusses characterization techniques for the aqueous film coating process and provides a useful influence matrix between process variables and final product attributes. 

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