Fever filgrastim

Contra PRO, breast-feeding Disp Inj SE BM, N/V/D, drug fever, skin rash Interactions T Myelosuppression W/ cisplatin, other neoplastic drugs, radiation therapy T in duration of neutropenia W/ filgrastim EMS Monitor for S/Sxs of Infxn OD May cause N/V/D and profound BM suppression s5miptomatic and supportive... 

Most cytokines (including TNF-o-, IFN-r, IL-2, G-CSF (filgrastim), and GM-CSF) have very short serum half-lives (minutes). The usual subcutaneous route of administration provides slower release into the circulation. Each cytokine has its own unique toxicity, but some toxicities are shared. Thus, IFN-n, IFN-B, IFN-r, IL-2, and TNF- all induce fever, flu-like symptoms, anorexia, fatigue, and malaise. 

Godwin et al " Filgrastim Yes Fewer days of fever and antibiotics... 

Filgrastim [G-CSF] (Neupogen) [Hematopoietic/Colony-Stimulating Factor] Uses i Incidence of Infxn in febrile neutropenic pts Rx clironic neutropenia Action Recombinant G-CSF Dose Adults Peds. 5 mcg/kg/d SQ or IV single daily dose D/C when ANC >10,000 ceUs/microL Caution [C, ] w/ dioigs that potentiate i elease of neutrophils (eg, Li) Contra Allergy to . co//-derived proteins or G-CSF Disp Inj mcg/mL SE Fever, alopecia, N/V/D,... 

Immunologic A 64-year-old woman developed persistent fever with mucositis and submandibular phlegm, not responsive to antibiotics. She was on therapy with mesalazine for ulcerative colitis, which was currently in remission, and levothyroxine for hypothyroidism. Laboratory tests showed leukopenia with severe neutropenia, and blood culture positive for multi-resistant Streptococcus oralis. The syndrome was managed with antibiotics and filgrastim. The latter drug yielded a scarce benefit, with a modest neutrophil count recovery, which was lost after its discontinuation. Mesalazine was then discontinued, and the patient had a complete and stable normalisation of her neutrophil count within the following 20 days [86 ]. 

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