Filgrastim cells

NEUPOGEN Filgrastim (G-CSF) Amgen Chemotherapy-induced neutropenia, bone marrow transplantation, chronic severe neutropenia, peripheral blood progenitor cell transplant... 

A), 3.8 billion Amgen s white blood cell stimulant, Neupogen (filgrastim), 3.0 billion interferon pia (Avonex for multiple sclerosis), 2.2 billion human growth hormone (HGH), 1.8 billion recombinant hepatitis B vaccine ( 1.0 billion) somatropin (Humatrope and Neutropin), 0.9 billion and cerezyme/ceredase (alglucerase), 0.6 billion. 

While filgrastim has proved a useful adjuvant to chemotherapy for many cancers, its administration in cases of myeloid leukaemia would give cause for concern, as these cells express receptors for G-CSF. In such cases, G-CSF could potentially promote accelerated growth of these malignant cells. 

Weaver CH, Schulman KA, Wilson-Relyea B, Birch R, et al. 2000. Randomized trial of Filgrastim, Sargramostim, or sequential sargramostim and filgrastim after myelosuppressive chemotherapy for the harvesting of peripheral blood stem cells. J Clin Oncol. 18 43-53. 

Fig. 15.6 Median cytokine (pegfiigrastim or filgrastim) concentrationtime profiles and ANC-time profiles in patients with non-small cell lung cancer before and after chemotherapy (n = 3-4 per cohort). (Adapted with permission from [35]).

G-CSF receptor through which pegfilgrastim and filgrastim act has been found on tumor cell lines including some myeloid, T lymphoid, lung, head and neck and bladder tumor cell lines... 

As a radiomimetic, HD affects rapidly dividing tissues like bone marrow in addition to the gastrointestinal tract (Sidell et al, 1997 Graham et al, 2005). HD destroys hematopoietic precursor cells WBCs have the shortest life span and decrease in number first, followed by RBCs and thrombocytes. The bone marrow suppression that is sometimes seen can be treated with filgrastim injections. This medication stimulates the bone marrow to create and release white blood cells. 

Filgrastim (r-metHuG-CSF) Neupogen (Amgen) Febrile neutropenias owing to myelosuppressive chemotherapy myeloid reconstitution after bone marrow transplantation severe chronic neutropenia peripheral blood progenitor cell transplant induction and consolidation therapy in AML... 

Few studies have directly compared the safety of the various available colony-stimulating factors. The frequency and severity of adverse effects associated with the prophylactic use of filgrastim (a bacterial cell-derived G-CSF) or sargramostim (a yeast cell-derived GM-CSF) have been assessed in a retrospective review of the medical records of 490 cancer patients from 10 centers (9). 

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