Fibrinoid

Passive diffusion is considered to be the major pathway by which xenobiotics cross the placenta. Paracellular diffusion was shown to be the predominant pathway for transfer of hydrophilic solutes, such as chloride ions across perfused placental lobes and opioid peptides and dextrans across BeWo cells [11-13], It has been proposed that denudations in the syncytiotrophoblasts-containing fibrinoid deposits provide a possible paracellular route across the placenta [14], Transtrophoblast channels in the syncytiotrophoblasts could also be responsible for this mode of diffusion [15], For more lipophilic solutes, the transplacental route appears to be the preferred mode of passage... 

Accelerated phase hypertension was previously called malignant hypertension because the lack of treatment heralded death within a year of diagnosis. It is characterised pathologically by fibrinoid necrosis of the small arteries. An important consequence is the loss of autoregulation of the cerebral and renal circulation, so that any reduction in blood pressure causes a proportional fall in perfusion of... 

Methylthioninium chloride marking of a colonic polyp resulted in an inflammatory mass with small arteries showing both segmental and circumferential fibrinoid necrosis with thrombosis (5). 

Borczuk AC, Petterino B, Alt E. Inflammatory mass with fibrinoid necrosis of vessels caused by methylene blue marking of a colonic polyp. Cardiovasc Pathol 1998 7 267-9. 

Some investigations have been made with the object of determining a possible role for hyaluronate in rheumatoid arthritis. This disease is characterized by fibrinoid degeneration, collagen decomposition, and lesions. It has been suggested that changes in either the concentration or the structure... 

Beginning as small macules and papules, they ultimately eventuate into purpuric lesions and, in the more severe cases, into hemorrhagic blisters and frank ulcerations. A polymorphonuclear infiltrate and fibrinoid changes in the small dermal vessels characterize the vasculitic reaction. 

Hyalinization and fibrinoid necrosis History of hypertension, especially with diabetes. Small lesion <1 cm diameter in the distal territory of the penetrator. Often multiple, bilateral, and even symmetrically placed lesions... 

Polyarteritis nodosa Arteriolar hemorrhage Fibrinoid necrosis... 

Monocrotaline pyrrole Vasoconstrictor acts on endothelin receptors and DNA in endothelial cells Small- and medium-sized intraacinar pulmonary arteries Fibrinoid change and smooth muscle cells hypertrophy Miyauchi et al. (1993)... 

Phosphodiesterase 4 inhibitors Vasodilator/inotrope Small- to medium-sized arteries in many organs including coronary arteries Medial fibrinoid necrosis, edema, hemorrhage, and surrounding inflammation Losco et al. (2004)... 

Inflammatory transmural angiitis in systemic lupus erythematosus, polyarteritis nodosa, or giant cell arteritis causes focal fibrinoid necrosis and elastic tissue disruption. Subacute or chronic changes usually produce ectasia and may facilitate aneurysm formation. Aneurysms in acute arteritis tend to be multiple, peripheral and non side-wall in configuration. 

Microscopically, toxocara granulomas consist of a central mass of karyorrhectic nuclear debris, and eosinophilic structureless and often fibrinoid-like material (Spencer 1973. In less severe tissue reactions the centres of the lesions are occupied by a mass of eosinophils without cellular necrosis. In a minority of lesions a portion of the causative larva may be identified near the centre of the lesion and cross sections may show the characteristic alar ridges projecting from the exterior of the cuticle. Around the central necrotic area the lesions consist of masses of eosinophil cells, plasma cells, lymphocytes and histiocytic cells, the latter often arranged in a characteristic pallisaded fashion. 

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