Fibrin stabilized

Fibrin-stabilizing factor is a protein involved with blood coagulation. 

XIII Fibrin-stabilizing factor Both Activated form cross-links fibrin, forming a hard clot... 

Protein-glutamine y-glutamyltransferase [Caj— fibrin-stabilizing factor ... 

XIII Fibrin-stabilizing ot-globulin. MW301kD 4-chains... 

Table 1 demonstrates that high lytic activity is displayed by the complexes of thrombin and fibrinogen as well as by that of heparin and plasmin. These complexes, as was shown in Ref.35), affect the unstabilized fibrin only and supress simultaneously the activity of the fibrin-stabilizing factor. Qualitatively similar results were observed in in vivo experiments. 

Ma — a characteristic of fibrinogen concentration, of the number and functional activity of platelets, and of fibrin stabilizing factor, cm 5.0 3.0... 

Sakata, Y., and Aoki, N. (1980). Cross-linking of a2-plasmin inhibitor to fibrin by fibrin-stabilizing factor./. Clin. Invest. 65, 290-297. 

Specific Factor Xllla inhibitors, such as tridegin and others mentioned earlier, may provide an interesting and novel approach to preventing fibrin stabilization. It is important to identify this polymorphism since the Leu34 variant associated with increased Factor Xllla activity reduces the activity of thrombolytic therapy (21,22). 

Heparin acts indirectly at multiple points within the coagulation cascade, Its major anticoagulant effect is via interaction with its requisite co-factor, antithrombin III (AT). The heparin-AT complex inactivates factors IXa, Xa, and XIla, and binds thrombin at its active site to prevent the conversion of fibrinogen to fibrin (3). Heparin also prevents fibrin stabilization through the inhibition of fibrin stabilization factor. Heparin has no fibrinolytic activity and therefore is ineffective as a thrombolytic (4,5). 

Figure 5.3. Intrinsic and extrinsic blood clotting cascades. Factor I, fibrinogen Factor II, prothrombin (vitamin K-dependent) Factor III, thromboplastin Factor V, proac-celerin Factor VII, proconvertin (vitamin K-dependent) Factor VIII, antihemophilic factor Factor IX, Christmas factor (vitamin K-dependent) Factor X, Stnart factor (vitamin K-dependent) Factor XI, plasma thromboplastin Factor XII, Hageman factor Factor XIII, fibrin-stabilizing factor and Factor XIV, protein C (vitamin K-dependent). What was at one time called Factor IV is calcinm no factor has been assigned nnmber VI.

XIII Laki-Lorand factor (= fibrin-stabilizing factor) + 0 4-6 days... 

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