Factor Xllla inhibitors

Specific Factor Xllla inhibitors, such as tridegin and others mentioned earlier, may provide an interesting and novel approach to preventing fibrin stabilization. It is important to identify this polymorphism since the Leu34 variant associated with increased Factor Xllla activity reduces the activity of thrombolytic therapy (21,22). 

In much the same way the number of interventions are possible at the level of fibrinolysis including thrombin-activateable fibrinolysis inhibitor, agents that block factor Xllla or inhibit plasminogen activator inhibitor therapy. 

Antifibrinolytic compounds can block the conversion of plasminogen to plasmin, or directly bind to the active site of plasmin to inhibit fibrinolysis. The plasma protein, a 2-macroglobulin, is a primary physiological inhibitor of plasmin. Plasmin released from fibrin is also very rapidly inactivated by a2-antiplasmin, which plays a role in the regulation of the fibrinolytic process (Aoki and Harpel, 1984). 2-anti plasmin inactivates plasmin in a very rapid reaction, interferes with plasminogen binding to fibrin, and is ligated to fibrin by Factor Xllla (Sakata and Aoki, 1980). After a2-antiplasmin is covalendy linked to fibrin s G-terminal a chain, it retains it ability to inhibit plasmin, a function that helps to prevent premature clot lysis. 

Inhibitor of factor Xllla 13 4 7 SN/S 88JAP63258428, 90MI 805-02,90M1 805-02... 

For example, the protease sensitive factor Xllla substrate sequence of a2-plasmin inhibitor (a2Plj g, NQEQVSPL (TG, transglutaminase substrate)) has been fused... 

Fibrinolytics. Figure 2 Various fibrin structures for plasmin. Fibrinogen (Fg) is converted to fibrin (F) by thrombin (T), and thrombin can also convert factor XIII (XIII) to activated factor XIII (Xllla). The latter produces crosslinks between fibrins (FxxF) and also may crosslink fibrin with a2-plasmin inhibitor (FxxFxxPI). The efficiency of digestion of these plasmin substrates by plasmin, resulting in the soluble fibrin degradation products (FDP), is different. The amount of FDP formed in time is expressed in arbitrary units. 

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