Fibers, bioabsorbable

Fu, B., Hsiao, B., Chen, G., Zhou J., Koyfman, I., Jamiolkowski D. D. and Dormier E., Structure and property studies of bioabsorbable poly(glycolide-co-lactide) fiber during processing and in vitro degradation. Polymer, 43,5527,2002. Fischer, E. W., Sterzel, H. J. and Wegner, G., Investigation of the structure of solution grown crystals of lactide copolymers by means of chemical reactions, Kolloid-Z. Z. Polym., 251,980. 1973. 

Park, J.-M., Kim, D.-S. and Kim, S.-R. (2003) Interfadal properties and microfailure degradation mechanisms of bioabsorbable fibers/poly-L-lactide composites using micromechanical test and nondestructive acoustic emission. Composites Science and Technology, 63, 403 19. 

M.W.King,Y.Marois,G.R.Marinov,J.P.Delagoutte and R.Guidoin, Monitoring the inflammatory response and rate of resorption of partially resorbable bicomponent fibers. Proceedings of ASTM Symposium on Synthetic Bioabsorbable Polymers for Implants, Kansas City, MO, USA, 16-17 Nov. 1999, p. 8. 

Regenerated cellulose fibers are uniform in diameter. This permits a tmiform oxidation and imparts uniform chemical and physical characteristics to the pharmaceutical material. In the early 1960 s, Johnson Johnson entered the market with an oxidized knitted rayon fabric, SURGICEL Absorbable Hemostat. Since then, Johnson Johnson has dev eloped a few other oxidized knitted rayon products. A list of currently av ailable bioabsorbable oxidized cellulose and oxidized regenerated cellulose products, and the respecthe manufacturer is contained in TkdUe 1. A list of relevant patents for oxidized cellulose technology is contained in IkUe 2. 

Yoshito, 1. (1989). Bioabsorbable fibers for medical use. In L. Menachem, J. Preston (Eds.), High technology fibers, part B (pp. 253—302). New York Marcel Dekker, Inc. 

Y. B. Peng and J. B. Koen, Bioabsorbable Glass Fiber/Polymer Composites, MO-SCI Corporation, Rolla, Missouri (June 30,1993). 

Non-bioabsorbable sutures are defined by their resistance to degradation by living tissues. They are most useful in percutaneous closures. Synthetic, non-bioabsorbable, monofilament sutures include nylon, polypropylene, and polybutester sutures, while synthetic, non-bioabsorbable, multifilament (braided) sutures are composed of nylon and polyester. Polybutester, developed in 2000, is a block copolymer that contains butylene terephthalate and telramethylene ether glycol. Metallic fibers such as steel fibers are also used extensively for suturing. 

Within the range of 16-24% carboxylic acid content, oxidized cellulose has a pH of approximately 3.1. The material is biocompatible, bioabsorbable, and hemostatic. Based on these unique properties, Johnson Johnson pioneered an industrial-scale oxidation process by using nitrogen dioxide to convert regenerated cellulosic fibers into oxidized regenerated cellulose (ORC) fibers. When knitted into a flexible fabric, ORC can be used as an absorbable hemostat in various surgical operations where blood loss should be controlled. 

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