Ferric picrate

Ferric Picrate. [C6H2(N02)3 0]3Fe.llH20, mw 938.4, N 13.44%, yellowish-red needles. Was prepd in 1911 by Kast by treating a hot satd soln of ferric sulfate with Ba picrate (Ref 1). Hopper (Ref 2) prepd several hydrated ferric pic rates of unknown w content which expld at 295. Their impact sensitivity ranged from 6 (for material dried at 150°), to 36" (for material dried at 25°) (PicArsn app with 2kg wt)... 

Picrates formed by precipitation from aqueous solutions contain water of crystallization which may desensitize them. For example, the decahydrate of ferric picrate shows no sensitiveness to friction and impact and cannot be ignited when in direct contact with a flame, whereas the anhydrous compound is exceptionally sensitive to these stimuli. 

Analysis. Dilute aqueous solutions of hydroxyhydroquiaone turn blue-green temporarily when mixed with ferric chloride. The solutions darken upon addition of small amounts, and turn red with additions of larger amounts of sodium carbonate. Derivatives used for identification are the picrate, which forms orange-red needles (mp of 96°C), and the triacetate (mp 96—97°C). Thin-layer chromatography and Hquid chromatography are well suited for the quahtative and quantitative estimation of hydroxyhydroquiaone (93,94). 

Brydon and Roberts- added hemolyzed blood to unhemolyzed plasma, analyzed the specimens for a variety of constituents and then compared the values with those in the unhemolyzed plasma (B28). The following procedures were considered unaffected by hemolysis (up to 1 g/100 ml hemoglobin) urea (diacetyl monoxime) carbon dioxide content (phe-nolphthalein complex) iron binding capacity cholesterol (ferric chloride) creatinine (alkaline picrate) uric acid (phosphotungstate reduction) alkaline phosphatase (4-nitrophenyl phosphate) 5 -nucleotidase (adenosine monophosphate-nickel) and tartrate-labile acid phosphatase (phenyl phosphate). In Table 2 are shown those assays where increases were observed. The hemolysis used in these studies was equivalent to that produced by the breakdown of about 15 X 10 erythrocytes. In the bromocresol green albumin method it has been reported that for every 100 mg of hemoglobin/100 ml serum, the apparent albumin concentration is increased by 100 mg/100 ml (D12). Hemolysis releases some amino acids, such as histidine, into the plasma (Alb). 

If ferric hydroxide be prepared by the hydrolysis of ferric chloride the resulting colloid contains chlorine ions which can be replaced by more readily adsorbable picrate or eosinate ions leaving hydrochloric acid in solution. 

Ferric nitrate, 107 Ferrous sulfate, 237 Fischer esterification, 248 Flavones, 13, 14,424 Fluoranthene picrate, 391 Fluorene-9-carboxylic acid, 101 Fluorenol, 455, 506... 

Wieland, 1907 Wieland and Wecker, 1910). Oxidation was carried out in an inert solvent such as benzene, from which the salt precipitated. The easier and more reliable preparation of perchlorate salts by the iodine-silver perchlorate method (Weitz and Schwechten, 1926, 1927), to which we have referred earlier (p. 168), allowed a much clearer understanding of the nature of triarylaminium ions to be obtained. Isolation of perchlorates permitted chemical studies, and easy reduction to the triarylamine by iodide ion, ferrous ion, etc., was consistent with the cation-radical view that was developed. The name aminium ion was coined by Weitz. Other salts were prepared such as tritolylaminium picrate (by oxidation of the amine with lead dioxide in the presence of picric acid), and it was also recognized that conjugate anions in salts obtained by oxidation with antimony pentachloride, phosphorus pentachloride and ferric chloride had to be complex anions rather than simple anionic radicals. This is a particularly pertinent point in antimony pentachloride oxidations (p. 165). 

It gives the Millon test, reduces cold ammoniacal silver nitrate solution and shows characteristic color reactions with ferric chloride followed by alkalies. The following salts are known hydrochloride, needles, very soluble in water, m.p. 241 hydrobromide, m.p. 212° tricarbomethoxy derivative, m.p. 92-93° tribenzoyl derivative, m.p. 141° picrate, m.p. 189° styphnate, m.p. 206°. 

Isolaudanosoline is the name given by Franck and Blaschke (196) to the tetraphenolic base CXXXIV (R = H). The tetramethyl derivative (CXXXIV R = CH3) [mp 76°-77° B HCI, 139°-141°] was prepared by Livshits et al. (197) who employed the Bischler-Napieralski reaction although they obtained instead of the usual dihydroisoquinoline base (CXXXV R = H2) the ketone CXXXV (R = O) whose methiodide on reduction afforded CXXXIV (R = CH3). In the absence of oxygen the dihydro base CXXXV (R = H2) can be prepared directly and its methiodide on reduction with sodium borohydride yields CXXXIV (R = CH3) [oil picrate, mp 189°]. When the methiodide of the latter base (CXXXVI R = CH3) was demethylated with hydrobromic acid the methobromide of isolaudanosoline was obtained (CXXXVI R = H). Its oxidation in aqueous solution with ferric chloride afforded an aporphine base (CXXXVII) [chloride, mp 225°-228° bromide, mp 170°-174°]... 

Irani has isolated from an alcoholic extract of kurchi seeds a crystalline gluco-alkaloid, which froths at 65°, melts at 200° (dec.), forms a benzoyl derivative and gjves a dark-green colour with ferric chloride. When a saturated solution of picric acid is added to an aqueous solution of the gluco-idkaloid hydrolysis occurs, the products t ing conessine picrate, a second piorate, m.p. 113-6°, and galactose. 

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