Female reproductive system postnatal development

The female reproductive system is also at risk during fetal development in utero, postnatally during puberty, and during her reproductive lifetime until menopause (cessation of ovulation). The traditional end points of concern are ovulation of a normal ovum, fertilization, uterine status, implantation and prenatal development, parturition, and lactation involving nursing (appropriate quality and quantity of milk) and other maternal behaviors. 

Normal pre- and postnatal male reproductive tract development. Progressive atrophy with age of rete testis and seminal tubules. Diminution of fertilizing capacity of sperm. Females Neuroendocrine system apparently normal, except for an excess of transcription of gonadotropin genes. 

At dosages above 30mg/kg in the diet, chlordane interfered with reproduction in rats and mice, but this effect was reversible after exposure ceased." Pre- and postnatal exposures to chlordane altered the development of the immune system in rodents. A dose-related increase in the incidence of hepatocellular carcinomas was found in male and female mice fed approximately 60mg/k chlordane for 80 weeks. In rats, increases in the incidences of thyroid follicular cell neoplasms were observed. ... 

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