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Felbamate development

Because felbamate-induced aplastic anemia might be linked to the formation of atropaldehyde, a urine screening test has been developed that indirectly assesses the formation of this toxic metabolite (8). The risk of serious toxicity may also be related to HLA status, and HLA typing is being performed in patients entered in the manufacturer s felbamate registry. The potential value of these tests in reducing the risk of toxicity remains to be established. [Pg.1329]

A 15-year-old boy with Lennox-Gastaut syndrome taking felbamate (3000 mg/day), topiramate(200 mg/ day), and lorazepam developed painful hematuria, bilateral urethral obstruction, and urinary retention. Kidney, bladder, and urethral stones were found. The stone material was identified as felbamate by chemical analysis. However, as the patient was also taking topir-amate the association with felbamate was uncertain. [Pg.1329]

A 32-year-old man developed infertility and a low sperm count (under 50 x 10 /1), with no motile sperm, less than 10% viability, and 100% with abnormal structure while taking valproate monotherapy for 5 years (96). Within 4 months of switching to felbamate, he and his wife conceived twin girls, and the sperm abnormalities were largely reversed. [Pg.3586]

A review of the second-generation anticonvulsants reveals that screening or serendipity led to the development of felbamate (10), 1am-otrigine (11), zonisamide (13), topiramate (15), and levetiracetam (16) on the other hand, clobazam (4d) and oxcarbazepine (12) were developed by structural variation of known agents (78). Only three, vigabatrin (8), gabapentin (9), and tiagabine (14), were developed by mechanism-based rational development (78). [Pg.299]

Rengstorff DS et al Felbamate overdose complicated by massive crystallurla ahd acute renal failure. J Toxicol Clin Tox/co/2000 38(6) 667-669. [PMID 11185976] (20-year-old woman with peak felbamate level of 470 mg/L developed massive crystallurla and hydronephrosis 18 hours after Ihgestloh, resolved with parenteral hydration.)... [Pg.87]

Urinary tract Four pediatric patients were reported to have urolithiasis, which was attributed to felbamate use. All patients were taking doses greater than 65 mg/d. Further examination of the stones showed that three of the four stones were radiolucent on X-ray and were pure felbamate stones the fourth stone had mixed composition containing felbamate and calcium phosphate. Three of the four patients went on to develop recurrent stones [66 ]. [Pg.90]


See other pages where Felbamate development is mentioned: [Pg.578]    [Pg.578]    [Pg.130]    [Pg.340]    [Pg.345]    [Pg.447]    [Pg.688]    [Pg.283]    [Pg.146]    [Pg.130]    [Pg.54]    [Pg.1254]    [Pg.1037]    [Pg.49]    [Pg.771]    [Pg.783]    [Pg.7]    [Pg.544]    [Pg.292]   
See also in sourсe #XX -- [ Pg.302 ]




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Felbamate

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