Felbamate

C3H7NO2 51-79-6) see Carisoprodol Felbamate Mebutamate Tybamate ethyl carbazate... 

C2H4O2 107-31-3) see Felbamate Hosequinan Fluphenazine Methyprylon Pyrithyldione Retinol methyl formimidate hydrochloride (CjH ClNO 15755-09-6) see Imipenem methyl ( )-2-formyl-2-phenylacetate sodium salt (C H,NaO, 246180-40-5) see Felbamate iV-methylglycine... 

The last few years has seen an explosion in AEDs. Some of those mentioned above may fall by the wayside and others appear. At the time of writing, we could include felbamate, zonisamide oxcarbazepine and topiramate. They all appear to have a phenytoin-like action on sodium channels, although topiramate appears to also potentiate the action of GABA on GABAa receptors like the benzodiazepines but through a different site. 

Acetazolamide, allopurinol, aspirin, captopril, carbamazepine, chloramphenicol, chlorpromazine, dapsone, felbamate, gold salts, metronidazole, methimazole, penicillamine, pentoxifylline, phenothiazines, phenytoin, propylthiouracil, quinidine, sulfonamide antimicrobials, sulfonylureas, and ticlopidine... 

Anticonvulsants (barbiturates, including phenobar-bital and primidone carbamazepine felbamate phenytoin topiramate vigabatrin)... 

The newer AEDs were first approved as adjunctive therapy for patients with refractory partial seizures. To date, lamotrigine, topiramate, and oxcarbazepine have received FDA approval for use in monotherapy in patients with partial seizures. Felbamate has monotherapy approval but causes significant side effects. 

Felbamate and topiramate can act as inducers with some isoforms and inhibitors with others. 

Felbamate appears to act by blocking N-methyl-D-aspartate responses and by modulating GABAa receptors. 

Case report evidence (probable Felbamate Oxacillin... 

Of all rat strains, the Brown Norway (BN) rat is used most frequently in relation to chemical-induced autoimmunity. This strain displays clinically manifested autoimmune disease following exposure to a number of chemicals. HgCl2 is the most scrutinized compound in the BN rat but D-penicillamine [6-8], gold-salts [9,10],hexachlorobenzene (HCB) [11-14] and recently, nevirapine [15], have all been shown to induce clinical effects. Captopril [7] and felbamate [16] appeared not to induce autoimmune effects in BN rats. 

Popovic, M. et al., Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions. Chern. Res. Toxicol., 17, 1568, 2004... 

FIGURE 8.12 Michael reaction of glutathione with acrolein and acrolein-like reactive metabolites of felbamate, terbinaflne, as well as the formation of a Michael acceptor metabolite of abacavir. 

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