Federal Interagency Testing Committee

Similar practices have been utilized by the Chemical Industry Institute of Toxicology in establishing their testing programs and by the Federal Interagency Testing Committee which functions under TSCA. 

EPA. 1991. Twenty-seventh report of the Interagency Testing Committee to the administrator receipt of report and request for comments regarding priority list of chemicals. U.S. Environmental Protection Agency. Federal Register 56(44) 9534. 

As a part of the Federal Hazardous Substances Act (FHSA), a modified Draize test was adopted (96-98) as the official method for evaluation of acute ocular irritancy (99). It is a pass/fail determination that remains in effect today. The test may use a small volume more consistent with the capacity of the inferior conjunctival sac (100), and incorporate biomicroscopic slit-lamp examination and/or fluorescein staining to assess ocular changes (71,97,98). While various in vitro tests have been proposed to replace this in vivo evaluation and a U.S. interagency committee has recommended certain in vitro tests to detect severe irritants and corrosives, none has yet been officially accepted or validated (101-104). 

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