FD C Yellow No. 6

Two others, FD C Yellow No. 5 (6) and Orange B (9), are pyra2olones that contain the foUowiag common group ... 

FD C Yellow No. 5 no appreciable change appreciable fade after 1 wk appreciable fade after 1 wk appreciable fade after 1 wk... 

Dyes. Dose does not appear to be a factor in patient reaction to dyes. The mandatory labeling of the azo dye tartrazine (FD C yellow No. 5) in OTC and prescription medications [58] has focused the attention of pharmaceutical manufacturers and the consumer on the potential danger of dyes in susceptible individuals. 

FD C Yellow No. 5 Aluminum Lake, in nail-care products, 7 853 FDA Bureau of Drug Abuse Control,... 

The color additive most often associated with adverse effects is FD C Yellow No. 5, or tartrazine (Jones, 1992 Fuglsang et al., 1993). From 1980... 

CJ Bailey, EA Cox, JA Springer. High pressure liquid chromatographic determination of the inter-mediates/side reaction products in FD C red no. 2 and FD C yellow no. 5 statistical analysis of instrument response. J Assoc Off Anal Chem 61(6) 1404-1414, 1978. 

MJ Prival, MD Peiperl, SJ Bell. Determination of combined benzidine in FD C yellow no. 5 (tartrazine). Food Chem Toxicol 33(10) 751-758, 1995. 

In 1985 the FDA published specifications for free amines in FD C Yellow No. 6 (or Sunset Yellow, l-(4 -sulfo-l -phenylazo-)2-naphthol-6-sulfonic acid disodium salt), and FD C Yellow No. 5 (or tartrazine, 4,5-dihydro5-oxo-l-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-l//-pyra-zole-3-carboxylic acid trisodium salt) and expressed concern about amines in other colors (208). 

Both the European Union and the FDA have pubhshed lists that are subject to regular review. The greatest concern has been expressed over the use of azodye colours as certain individuals can demonstrate an allergic reaction to some of these. Allergic reactions have been reported most frequently for sunset yellow (E110, FD C yellow no. 6) and tartrazine (E102, FD C yellow no. 5). 

E. A. Cox and F. D. McClure, High-performance liquid chromatographic determination of intermediates and reaction byproducts in FD C yellow No. 5 Collaborative study, J. Assoc. Off. Anal. Chem., 65 933 (1982). 

FD C Yellow No. 5 is principally the trisodium salt of 4,5-dihydro-5-oxo- l-(4-sulfophenyl)-4-[4-sulfophenyl-azo]-1H-pyrazole-3-carboxylic acid. 

Identification The visible absorption spectrum of a sample of FD C Yellow No. 5 dissolved in 0.04 N aqueous ammonium acetate has a wavelength maximum of 428 nm, with an absorptivity of 0.053 L/(mg cm). 

To be used or sold for use to color food that is marketed in the United States, this color additive must be from a batch that has been certified by the U.S. Food and Drug Administration (FDA). If it is not from an FDA-certified batch, it is not a permitted color additive for food use in the United States, even if it is compositionally equivalent. The name FD C Yellow No. 5 can be applied only to FDA-certified batches of this color additive. Tartrazine is a common name given to the uncertified colorant. See the monograph entitled FD C Yellow No. 5 for directions for producing an FDA-certified batch. 

Tofranil-PM(r) (imipramine pamoate) 100-and 125-mg capsules contain the dye tartrazine (FD C yellow No. 5), which may cause allergic reactions in some patients this reaction is more likely in patients with sensitivity to aspirin... 

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