FAIMS waveform analysis

DGE a AC AMS APCI API AP-MALDI APPI ASAP BIRD c CAD CE CF CF-FAB Cl CID cw CZE Da DAPCI DART DC DE DESI DIOS DTIMS EC ECD El ELDI EM ESI ETD eV f FAB FAIMS FD FI FT FTICR two-dimensional gel electrophoresis atto, 10 18 alternating current accelerator mass spectrometry atmospheric pressure chemical ionization atmospheric pressure ionization atmospheric pressure matrix-assisted laser desorption/ionization atmospheric pressure photoionization atmospheric-pressure solids analysis probe blackbody infrared radiative dissociation centi, 10-2 collision-activated dissociation capillary electrophoresis continuous flow continuous flow fast atom bombardment chemical ionization collision-induced dissociation continuous wave capillary zone electrophoresis dalton desorption atmospheric pressure chemical ionization direct analysis in real time direct current delayed extraction desorption electrospray ionization desorption/ionization on silicon drift tube ion mobility spectrometry electrochromatography electron capture dissociation electron ionization electrospray-assisted laser desorption/ionization electron multiplier electrospray ionization electron transfer dissociation electron volt femto, 1CT15 fast atom bombardment field asymmetric waveform ion mobility spectrometry field desorption field ionization Fourier transform Fourier transform ion cyclotron resonance... 

Today, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are considered the standard ionization techniques for LC-MS/MS due to their predominant advantages in quantitative analysis of drug molecules in various sample matrices with high sensitivity, selectivity, reliability, robustness, and ease of operation. Other techniques, for example, atmospheric pressure photoionization (APPI), electron capture atmospheric pressure chemical ionization (EC-APCI), and high-field asymmetric waveform ion mobility mass spectrometry (FAIMS) serve as complements to the established ESI and/or APCI technical platforms whenever necessary for an enhanced sensitivity and/or selectivity of a bioanalytical assay [4,5]. 

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