Fagara macrophylla, isobutylamide isolation

Five isobutylamides were isolated as insect growth inhibitors and toxicants from Fagara macrophylla and identified from their spectroscopic and chemical data. Synthesis and bioassay of the five natural products plus four analogs showed pellitorine to be the most active against a variety of insects, but not against a species of snail. 

Biologically active isobutylamides have been isolated from plants of the Compositae and the Rutaceae. Some of the isohutyla-mides were found to have paralytic and toxic activities against insects, especially when applied topically to several species of Coleopterans and Dipterans.The present work describes the isolation, spectral identification, synthesis, and insect and snail bioassays of five isobutylamides from the Rutaceae plant, Fagara macrophylla. In addition, the synthesis and bioassay of four analogs of the isbbutylamide natural products are described. 

Five known isobutylamides, namely fagaramide, piperlongumine, 4,5-dihydropiperlongumine, pellitorine, and (2 ,4 )-A-isobutylocta-2,4-dienamide, were isolated as the molluscidal and insecticidal active principles from Fagara macrophylla (Rutaceae) (112). 

Kubo I, Matsumoto T, Klocke J A, Kamikawa T 1984 Molluscicidal and insecticidal activities of isobutylamides isolated from Fagara macrophylla. Experientia 40 340-341... 

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