Factory layout

Factory layout has a significant bearing on safety. Relevant considerations include ... 

Prior to considering the factory layout the designer must understand the risks to the production environment. These come from factors external to the plant, transmission media into the plant and internal factors resulting from operations within the plant. Table 8.1 details some examples of risk factors. Measures must be designed into the factory to eliminate or control all the risks to acceptable levels. 

Figure 8.5 Factory layout showing material flow.

Figure 8.6 Factory layout showing people flow.

Figure 8.7 Factory layout showing waste flow.

To gain maximum efficiency from a production line it is normal for the machinery upstream and downstream of the filler to ran faster than the filler and to provide accumulation between machines so that minor stoppages (for example changing the shrink-wrap reel) can be accommodated without stopping the filler. Figure 8.9 illustrates this for the factory layout shown in Figure 8.8. 

Autoclaves are usually installed in high, light rooms equipped with traveling hoists. Figure 56 on page 376 shows, in cross section, a factory layout for a dye plant with its adjoining autoclave room. The illustration shows how the completed reaction mixture is transferred directly from the autoclave to the processing rooms. 

For overseas manufacturer, please submit a brief write up of the factory layout, facilities for manufacturing and quality control and state the types of pharmaceutical dosage forms manufactured in the plant. ... 

Scalability provides technical, spatial, and personnel extensibility. In particular this enabler provides for spatial degrees of freedom, regarding expansion, growth, and shrinkage of the factory layout. 

To factory planners who prepare a factory layout for you that is optimized in regard to the material flow ... 

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