F Diisopropyl ether

Many incidents involving explosions have been attributed, not always correctly, to peroxide formation and violent decomposition. Individually indexed incidents are 2-Acetyl-3-methyl-4,5-dihydrothiophen-4-one, 2807 Aluminium dichloride hydride diethyl etherate, Dibenzyl ether, 0061 f 1,3-Butadiene, 1480 f Diallyl ether, 2431 f Diisopropyl ether, 2542... 

D/chloro-5-Cyclohexyl-2-Oxo-2,3-D/hydro 1 H-Benzo(fj-Diazepine-1,4 fa) Process Using Sodium Hypochlorite — 40 ml of a solution of sodium hypochlorite of 14.5 British chloro-metric degrees are added to a suspension of 5.4 grams of 7 chloro-5 cyclohexyl-2 oxo-2,3-dihydro 1 H-benzo(f)diazepine-1,4 in BO ml of methylene chloride. The mixture is stirred at room temperature for 15 minutes the solid dissolves rapidly. The organic iayer is decanted, washed with water, dried over anhydrous Sodium sulfate and the solvent evaporated under reduced pressure without exceeding a temperature of 30 C. The residue is taken up in a little diisopropyl ether and the crystals which form are dried. They are recrystallized as rapidly as possible from ethyl acetate. Colorless crystals are obtained (3.9 grams yield, B5%) MP < = 163°C, with decomposition. 

A solution of (R)-oxynilrilase (F.C 4.1.2.10, 100 pi., 1000 unils/ml.) is dropped onto 1.5 g of Avicel cellulose (soaked in 0.02 M sodium acetate buffer. pH 4.5). 20 mL of diisopropyl ether are added, followed by 5 mmol of ketone and 200 pL of hydrocyanic acid, and the mixture is stirred (Table 3). The catalyst is filtered off. washed with diisopropyl ether, and the combined filtrates are concentrated. 

J. F. Knifton, R. J. Taylor, and P.E. Dai, Diisopropyl ether one-step generation from acetone-rich feedstocks, Chemical Industries (Dekker) 85 Catal. Org. React.) 131-141 (2002). 

Oxygen (Gas), Carbon disulfide, Mercury, Anthracene, 4831 Oxygen (Liquid), Carbon, Iron(II) oxide, 4832 Oxygen difluoride, Hexafluoropropene, Oxygen, 4317 Potassium chlorate, Manganese dioxide, 4017 f Propionyl chloride, Diisopropyl ether, 1163 f Propylene oxide, Sodium hydroxide, 1225 Silver azide, 0023 Silver nitride, 0038 Sodium carbonate, 0552 Sodium peroxoborate, 0155 Tetrafluoroammonium tetrafluoroborate, 0133 Triallyl phosphate, 3184... 

Problem 14.6 Give the alkene and alcohol needed to prepare the following ethers by alkoxymercuration-demercuration (a) diisopropyl ether, (b) 1-methyl-l-methoxycyclopentane, (c) 1-phenyl-1-ethoxypropane, (d) di-f-butyl ether. ... 

MTBE methyl f-butyl ether THF tetrahydrofuran EA ethyl acetate C6H12. cyclohexane DIPE diisopropyl ether DMF dimethylformamide. 

A Avicel, ethyl acetate/HOAc-buffer (pH 5.4), HCN, rt. B almond meal, ethyl acetate/citrate buffer (pH 5.5), HCN, 4°C. C EtOH/HOAc-buffer (pH 5.4), HCN, 0°C. D Avicel, diisopropyl ether/HOAc-buffer (pH 3.3), HCN, RT. E almond meal, diisopropyl ether/citrate buffer (pH 5.5), acetone cyanohydrin, RT. F Et,O/HOAc-buffer (pH 5.0), acetone cyanohydrin, RT. G almond meal, methyl f-butyl ether/citrate buffer (pH 5.5), HCN, 5 °C. 

DIISOPROPYL ETHER (108-20-3) Forms explosive mixture with air (flash point - 18°F/-28°C). Exceptionally vulnerable to the formation of unstable peroxides that precipitate as dry crystalline material and may detonate with heat, shock, sunlight, or friction. Violent reaction with strong oxidizers, propionyl chloride, strong acids, chlorosulfonic acid, nitric acid. Attacks some plastics, rubber, and coatings. Flow or agitation of substance may generate electrostatic charges due to low conductivity. 

Sample preparation 1 mL Serum or plasma -I- 1 mL saturated Na2HP04 -I- 100 p.L 10 lAg/mL IS -f 5 mL diisopropyl ether isopropanol 95 5 (Caution Diisopropyl ether readily forms explosive p>eroxides ), shake for 5 min, centrifuge. Remove the organic layer and evaporate it to drsmess at 35°, reconstitute the residue in 50 p.L mobile phase, vortex, inject a 20 p.L aliquot. 

Propanol undergoes reactions characteristic of a secondary —OH group. Oxidation is highly exothermic (43 kcal/mol) but occurs above 300° C (572°F), forming acetone. It reacts with acid chlorides, chlorine, and phosphorus chloride to produce chloroacetones (toxic). It loses water molecules over acid catalysts such as alumina or sulfuric acid, to form diisopropyl ether (flammable) and propylene (flammable, forms an explosive mixture with air). It forms isopropyl acetate (mucous membrane irritant, narcotic) with acetic acid. Treatment with nitrosyl chloride or with sodium... 

Isopropyl ether (diisopropyl ether [CAS 108-20-3]) A skin irritant upon prolonged contact ith liquid. Vapors mildly irritating to the eyes and respiratoiy tract. A CNS depressant. 250 ppm 1400 ppm [LEL] 1 3 1 Coloriess liquid. Oifensive and sharp ether-like odor and Irritation are good warning properties. Vapor pressure is 119 mm Hg at 20°C (68°F). Highly flammable. Contact with air causes fomnadon of explosive peroxides. 

Fig. 122. Two-dimensional separation of the naturally occurring tocopherols (T) and tocotrienols (T-3) on activated, 0.25 mm silica gel G layers. Solvents a chloroform (CS) h diisopropyl ether-petrol ether (BP 40—60° C) (20 -f 80) (NS). 10 p.g of each applied to the start point (x) [104, 105, 146]...

Heptane-diethyl ether (92 + 8) Heptane-diethyl ether (70 + 30) Benzene-diethyl ether (80 4- 20) Benzene-acetone (92 + 8) Benzene-acetone (86 + 15) Bi-n-butyl ether-acetone (85 + 15) Benzene-acetone (70 + 30) Di-n-butyl ether-acetone (70 + 30) Benzene-ethyl acetate (20 + 80) Isooctane-ethyl acetate-acetic acid (50 f 50 + 0.6 to 2.0) Isooctane-diisopropyl ether-acetic acid (50 + 25 + 25) Benzene-dioxan-acetic acid (75 + 20 + 2)... 

X. Diisopropyl ether-formic acid-water (90 + 7 -f 3), saturated with polyethylene glycol M 1000 use of the M 4000 gives rise to small deviations. 

XIV. Diisopropyl ether-petrol ether-carbon tetrachloride-formic acid-water (50 -f 20 + 20 + 8 + 1). 

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