Extracellular matrix protein fibronectin

It is suggested that the bicyclic diastereoisomeric fr.mr-azetidine 519 is a convenient nonpeptidic framework which mimics the /3-turn topology of the Arg-Gly-Asp (RGD) tripeptide portion of the extracellular matrix protein, fibronectin, involved in cell adhesion <2003BML1561>. 

Fibronectin is an extracellular matrix protein that mediates a variety of cellular effects. It is important in cell-cell and cell-substratum interactions ( 3.9), mediates reticuloendothelial cell activity and binds both to Clq (the first component of complement) and to bacteria. It also increases the tu-mouricidal activity of macrophages and activates complement receptors, by regulating the binding of C3b-coated particles to neutrophils. It may mediate attachment of Staphylococcus aureus to neutrophils and may also play a role as an adhesion factor, promoting the adhesion of neutrophils to surfaces. Fibronectin mRNA (8.7-8.8 kb) is detected only at low levels in... 

Figure. 4. Principle of the cell adhesion to artificial materials. In cell culture media or body fluids, the material is spontaneously adsorbed with cell adhesion-mediating extracellular matrix proteins (e g., vitronectin, fibronectin). The cells then adhere to specific amino acid sequences of these proteins by their adhesion receptors of integrin or non-integrin type [38-41].

Gateau E, Levasseur P, Borgonovi M, Imbert C. (2007) The effect of aminocandin (HMR 3270) on the in vitro adherence of Candida Albicans to polystyrene surfaces coated with extracellular matrix proteins or fibronectin. Clin Microbiol Infec 13 311-315. 

Panitch, A., Yamaoka, T., Fournier, M. J., Mason, T. L., and Tirrell, D. A. (1999). Design and biosynthesis of elastin-like artificial extracellular matrix proteins containing periodically spaced fibronectin CS5 domains. Macromolecules 32, 1701-1703. 

Fibronectin is a cell-surface compound with domains that interact with many compounds, including integrins and extracellular matrix proteins such as collagen. Fibronectin expression can be stimulated by I GF-[3 and by CTGF,41 although increases in fibronectin expression can also be mediated by TGF-(3-independent means 42 We found some evidence of increased expression of fibronectin in FBC tissue, but not to the degree in which I GF-[3, CTGF, and decorin were expressed.16,17... 

These serine proteases are used to remove pathogens by their hydrolytic activity. They degrade cell membrane proteins and connective tissue matrices by hydrolysis of extracellular matrix proteins such as fibronectin, type IV collagen and laminin, or solubilizing fibrous elastins [55, 56]. Immune cell proteases also are capable of cleaving cytokines, growth hormone, neuropeptides, and procoagulant proteins such as Factors X and V. 

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